Diabetes mellitus und Demenz

Daniel Kopf

doi:10.1055/a-1666-5769

Geriatrie up2date, Table of Contents

Geriatrie up2date 2022; 04(01): 25-38
DOI: 10.1055/a-1666-5769

Weitere Teilgebiete der Inneren Medizin

Diabetes mellitus und Demenz

Authors

Daniel Kopf

¹Geriatrische Klinik und Zentrum für Altersmedizin, Klinikum Ludwigsburg, Ludwigsburg, Deutschland

Abstract

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Diabetes mellitus und Demenz werden mit zunehmendem Lebensalter häufiger, sind wegen der demografischen Entwicklung in Deutschland auf dem Vormarsch und beeinträchtigen die Lebensqualität erheblich. Sie hängen auch in ihrer Krankheitsentstehung zusammen: Bei Demenz liegt eine Insulinresistenz des Gehirns vor. Das Zusammentreffen der beiden Störungen erschwert die Behandlung erheblich, sodass neue Therapieziele und Konzepte erforderlich sind.

Schlüsselwörter

Diabetes mellitus - Demenz - Hypoglykämie - Adipositas - Gewichtsverlust

Keywords

diabetes mellitus - dementia - hypoglycemia - obesity - weight loss

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References

Literatur
1 Nicastri C, Hensley J, Lane S. Managing the Forgetful Patient: Best Practice for Cognitive Impairment. Med Clin North Am 2021; 105: 75-91
2 Matej R, Tesar A, Rusina R. Alzheimer’s disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview. Clin Biochem 2019; 73: 26-31
3 Zhang Q, Sidorenko J, Couvy-Duchesne B. et al. Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nat Commun 2020; 11: 4799
4 Mons U, Parna L, Brenner H. Alzheimer-Risikofaktor ApoE-E4: Hat der Cholesterinspiegel Einfluss auf die Kognition?. Dtsch Arztebl 2016; 113: 28
5 Liang JH, Lu L, Li JY. et al. Contributions of Modifiable Risk Factors to Dementia Incidence: A Bayesian Network Analysis. J Am Med Dir Assoc 2020; 21: 1592-1599.e13
6 Musen G, Tinsley LJ, Marcinkowski KA. et al. Cognitive function deficits associated with long-duration type 1 diabetes and vascular complications. Diabetes Care 2018; 41: 1749-1756
7 Kopf D, Frölich L. Risk of incident Alzheimer’s disease in diabetic patients: a systematic review of prospective trials. J Alzheimers Dis 2009; 16: 677-685
8 Craft S, Raman R, Chow TW. et al. Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease dementia: a randomized clinical trial. JAMA Neurol 2020; 77: 1099-1109
9 Fitzpatrick AL, Kuller LH, Lopez OL. et al. Diehr P et al. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch Neurol 2009; 66: 336-342
10 Perera G, Rijnbeek PR, Alexander M. et al. Vascular and metabolic risk factor differences prior to dementia diagnosis: a multidatabase case-control study using European electronic health records. BMJ Open 2020; 10: e038753
11 Willette AA, Bendlin BB, Starks EJ. et al. Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. JAMA Neurol 2015; 72: 1013-1020
12 Kellar D, Craft S. Brain insulin resistance in Alzheimer’s disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol 2020; 19: 758-766
13 Peters A. The selfish brain: Competition for energy resources. Am J Hum Biol 2011; 23: 29-34
14 Folstein MF, Folstein SE, McHugh PR. „Mini-mental state“. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198
15 Shulman KI, Gold DP, Cohen CA. et al. A longitudinal study. Int J Geriatr Psych 1993; 8: 487-496
16 Kessler J, Calabrese P, Kalbe E. et al. DemTect: A new screening method to support diagnosis of dementia. Psycho 2000; 26: 343-347
17 Nasreddine ZS, Phillips NA, Bédirian V. et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53: 695-699
18 Nikolaus T, Bach M, Specht-Leible N. et al. The Timed Test of Money Counting: a short physical performance test for manual dexterity and cognitive capacity. Age Ageing 1995; 24: 257-258
19 Gardener SL, Rainey-Smith SR. The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly. Curr Nutr Rep 2018; 7: 139-149
20 Stephen R, Hongisto K, Solomon A. et al. Physical Activity and Alzheimer’s Disease: A Systematic Review. J Gerontol A Biol Sci Med Sci 2017; 72: 733-739
21 Jacobson AM, Musen G, Ryan CM. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group. et al. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 2007; 356: 1842-1852
22 Frier BM. Cognitive functioning in type 1 diabetes: the Diabetes Control and Complications Trial (DCCT) revisited. Diabetologia 2011; 54: 233-236
23 Murray AM, Hsu FC, Williamson JD. et al. Action to Control Cardiovascular Risk in Diabetes Follow-On Memory in Diabetes (ACCORDION MIND) Investigators. ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial. Diabetologia 2017; 60: 69-80
24 Whitmer RA, Karter AJ, Yaffe K. et al. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009; 301: 1565-1572
25 Lacy ME, Gilsanz P, Eng C. et al. Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID). Diabetes Care 2020; 43: 541-548
26 Kaiser MJ, Bauer JM, Ramsch C. MNA-International Group. et al. Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging 2009; 13: 782-788
27 Deutsche Diabetes Gesellschaft. S2k-Leitlinie Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Alter. AWMF-Registernummer: 057–017. 2. Auflage. 2018 Im Internet (Stand: 03.12.2021): https://www.awmf.org/leitlinien/detail/ll/057–017.html