Application of α-Aminoalkyl Radicals as Reaction Activators

Abstract

α-Aminoalkyl radicals are easily accessible through multiple pathways from various precursors. Apart from their utilization as nitrogen-containing building blocks, they have recently been used as halogen atom abstraction reagents or single-electron reductants to transform organic halides or sulfonium salts into their corresponding highly reactive radical species. Benefiting from the richness of various halides and the diverse reactivity of radical intermediates, new transformations of halides and sulfonium salts have been developed. This short review summarizes this emerging chemistry that uses α-aminoalkyl radicals as the reaction activators.

1 Introduction

2 Activation of Halides as Halogen-Atom Transfer Agents

2.1 Addition to Unsaturated Bonds

2.1.1 Addition to C=C Bonds

2.1.2 Addition to C=O Bonds

2.2 Substitution Reactions

2.2.1 Deuteration

2.2.2 Olefination

2.2.3 Allylation

2.2.4 Aromatic Substitution

2.2.5 Amination

3 Activation of Sulfonium Salts as Single-Electron Reductants

4 Conclusion and Outlook

Key words

α-aminoalkyl radicals - halides - halogen-atom transfer - hydrogen-atom transfer - radical addition - radical substitution - sulfonium salts

Publikationsverlauf

Eingereicht: 28. September 2021

Angenommen nach Revision: 03. November 2021

Accepted Manuscript online:
03. November 2021

Artikel online veröffentlicht:
15. Dezember 2021

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