Pregnancy After Simultaneous Pancreas-Kidney Transplantation in
                    Treatment of End-Stage Diabetes Mellitus: a Review

Zana Stanic; Marko Vulic; Zlatko Hrgovic; Rajko Fureš; Milvija Plazibat; Esma Cecuk; Iva Vusic; Marko Lagancic

doi:10.1055/a-1710-4097

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2022; 226(02): 86-91
DOI: 10.1055/a-1710-4097

Review

Pregnancy After Simultaneous Pancreas-Kidney Transplantation in Treatment of End-Stage Diabetes Mellitus: a Review

Authors

Zana Stanic

¹Department for Integrative Gynecology, Obstetrics and Minimally invasive Gynecologic Surgery, Zabok General Hospital, Zabok, Croatia
Marko Vulic

²Department of Gynaecology and Obstetrics, Clinical Hospital Center Split, Split, Croatia
Zlatko Hrgovic

³Gynecology and Women's Health Department, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany
Rajko Fureš

¹Department for Integrative Gynecology, Obstetrics and Minimally invasive Gynecologic Surgery, Zabok General Hospital, Zabok, Croatia
Milvija Plazibat

⁴Department of Pediatrics, Zabok General Hospital, Zabok, Croatia
Esma Cecuk

⁵Center for transfusion and transplant medicine, Clinical Hospital Center Split, Split, Croatia
Iva Vusic

⁶Emergency Department, Bjelovar General Hospital, Bjelovar, Croatia
Marko Lagancic

⁷Emergency Department, Dubrava Clinical Hospital, Zagreb, Croatia

Abstract

The majority of patients with simultaneous pancreas and kidney transplant (SPKT) required transplantation owing to a long-standing history of insulin-dependent diabetes mellitus (IDDM). The disease causes multiple organ damage, impairs fertility, and affects quality of life. A successful kidney and pancreas transplant can improve health, ameliorate the consequences of pre-existent diabetes, and restore fertility. Good graft function, without any sign of rejection, and stable doses of immunosuppressant drugs are of utmost importance prior to the planned pregnancy. SPKT recipients who become pregnant may be at an increased risk for an adverse outcome and require meticulous multidisciplinary surveillance. We present experiences with SPKT pregnancies, traditional approaches, and recent considerations. In light of complex interactions between new anatomic relations and the impact of developing pregnancy and immunosuppressive medications, special stress is put on the risk of graft rejection, development of pregnancy complications, and potential harmful effects on fetal development. Recent recommendations in management of SPKT recipients who wish to commence pregnancy are presented as well. Key words: transplantation, pregnancy, pancreas, kidney, simultaneous pancreas and kidney transplantation (SPKT)

Key words

transplantation - pregnancy - pancreas - kidney - simultaneous pancreas and kidney transplantation (SPKT)

Full Text

References

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