Endoscopy 2022; 54(09): 871-880
DOI: 10.1055/a-1726-9144
Original article

Impact of surgical versus endoscopic management of complex nonmalignant polyps in a colorectal cancer screening program

Maaike Buskermolen
1   Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands
,
Steffie K. Naber
1   Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands
,
Esther Toes-Zoutendijk
1   Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands
,
Miriam P. van der Meulen
1   Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands
,
Wilhelmina M. U. van Grevenstein
2   Department of Surgery, University Medical Center, Utrecht, the Netherlands
,
Monique E. van Leerdam
3   Department of Gastroenterology, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
,
4   Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands
,
Iris Lansdorp-Vogelaar
1   Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands
› Author Affiliations

Abstract

Background When complex nonmalignant polyps are detected in colorectal cancer (CRC) screening programs, patients may be referred directly to surgery or may first undergo additional endoscopy for attempted endoscopic removal by an expert. We compared the impact of both strategies on screening effectiveness and costs.

Methods We used MISCAN-Colon to simulate the Dutch screening program, and projected CRC deaths prevented, quality-adjusted life-years (QALYs) gained, and costs for two scenarios: 1) surgery for all complex nonmalignant polyps; 2) attempted removal by an expert endoscopist first. We made the following assumptions: 3.9 % of screen-detected large nonmalignant polyps were complex; associated surgery mortality was 0.7 %; the rate of successful removal by an expert was 87 %, with 0.11 % mortality.

Results The screening program was estimated to prevent 11.2 CRC cases (–16.7 %) and 10.1 CRC deaths (–27.1 %), resulting in 32.9 QALYs gained (+ 17.2 %) per 1000 simulated individuals over their lifetimes compared with no screening. The program would also result in 2.1 surgeries for complex nonmalignant polyps with 0.015 associated deaths per 1000 individuals. If, instead, these patients were referred to an expert endoscopist first, only 0.2 patients required surgery, reducing associated deaths by 0.013 at the expense of 0.003 extra colonoscopy deaths. Compared with direct referral to surgery, referral to an expert endoscopist gained 0.2 QALYs and saved €12 500 per 1000 individuals in the target population.

Conclusion Referring patients with complex polyps to an expert endoscopist first reduced some surgery-related deaths while substantially improving cost-effectiveness of the screening program.

Supplementary material



Publication History

Received: 04 May 2021

Accepted: 29 November 2021

Article published online:
07 February 2022

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