Abstract
Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques
play significant role on antioxidant status. In this study, we aimed to show the relationship
between early cord clamping (ECC), delayed cord clamping (DCC), and cut–umbilical
cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant
capacity (TAC), and peroxynitrite levels.
Study Design Sixty-nine term infants were selected with Apgar's score of 7 and above in the 1 minute
and 5 minutes. The mothers of all infants had uncomplicated pregnancy, had no congenital
anomaly, and delivered by cesarean section. Newborns were randomized to one of three
groups: ECC (n: 23), DCC (n: 23), or C-UCM (n: 23). After all newborn babies were taken under radiant heater, blood samples were
collected from the UC. The plasma samples were then frozen and stored at −80°C until
analysis and TOC, TAC, and peroxynitrite levels were studied.
Results The ages of the mothers participating in the study were between 17 and 42 years,
with an average of 29.14 ± 6.28. Thirty (43.5%) of the babies were girls and 39 (56.5%)
were boys. The 5-minute Apgar's score of the babies in ECC group was significantly
lower than the babies in DCC and cut cord milking group (p = 0.034; p = 0.034; p < 0.05). The TOC, oxidative stress index (OSI), and peroxynitrite measurements of
three groups did not differ statistically. The TAC value of the C-UCM group was significantly
higher than the patients with the ECC and DCC groups (p = 0.002; p = 0.019; p < 0.05).
Conclusion C-UCM and DCC would be feasible methods by increasing antioxidant status and providing
protective effect on the future health of the term newborns.
Key Point
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Cord clamping techniques play significant role on antioxidant status of the newborn
babies.
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C-UCM and DCC are feasible methods for term newborns.
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Cord clamping methods may play a protective effect on the future health of term newborns.
Keywords
umbilical cord - milking - oxidant - antioxidant - peroxynitritis
