Update Mammakarzinom 2021 Teil 3 – aktuelle Entwicklungen bei der Behandlung von Brustkrebspatientinnen mit frühen Krankheitsstadien: Übersicht und Beurteilung von speziellen Therapiesituationen durch ein internationales Expertenpanel

Tanja N. Fehm; Elmar Stickeler; Peter A. Fasching; Wolfgang Janni; Cornelia Kolberg-Liedtke; Hans-Christian Kolberg; Diana Lüftner; Volkmar Müller; Florian Schütz; Christoph Thomssen; Erik Belleville; Annika Behrens; Simon Bader; Michael Untch; Manfred Welslau; Rachel Würstlein; Marc Thill; David Krug; Andreas D. Hartkopf

doi:10.1055/a-1755-5749

Senologie - Zeitschrift für Mammadiagnostik und -therapie, Inhaltsverzeichnis

Senologie - Zeitschrift für Mammadiagnostik und -therapie 2022; 19(01): 75-87
DOI: 10.1055/a-1755-5749

Übersicht

Update Mammakarzinom 2021 Teil 3 – aktuelle Entwicklungen bei der Behandlung von Brustkrebspatientinnen mit frühen Krankheitsstadien: Übersicht und Beurteilung von speziellen Therapiesituationen durch ein internationales Expertenpanel

Update Breast Cancer 2021 Part 3 – Current Developments in the Treatment of Early Breast Cancer: Review and Assessment of Specialised Treatment Scenarios by an International Expert Panel

Tanja N. Fehm

¹Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf

,

Elmar Stickeler

²Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen

,

Peter A. Fasching

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Wolfgang Janni

⁴Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm

,

Cornelia Kolberg-Liedtke

⁵Department of Gynecology and Obstetrics, University Hospital Essen, Essen

⁶palleos healthcare, Wiesbaden

⁷Phaon Scientific, Wiesbaden

,

Hans-Christian Kolberg

⁸Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop

,

Diana Lüftner

⁹Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin

,

Volkmar Müller

¹⁰Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg

,

Florian Schütz

¹¹Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer

,

Christoph Thomssen

¹²Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale)

,

Erik Belleville

¹³ClinSol GmbH & Co KG, Würzburg

,

Annika Behrens

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Simon Bader

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Michael Untch

¹⁴Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin

,

Manfred Welslau

¹⁵Onkologie Aschaffenburg, Aschaffenburg

,

Rachel Würstlein

¹⁶Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich

,

Marc Thill

¹⁷Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt

,

David Krug

¹⁸Department of Radiation Oncology, University Hospital of Schleswig-Holstein, Kiel

,

Andreas D. Hartkopf

¹⁹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen

› Institutsangaben

Abstract

Zusammenfassung

Kontinuierlich neue Studienergebnisse führen wiederholt zu aktualisierten Therapieempfehlungen und Leitlinien. Insbesondere beim Mammakarzinom wurden in den letzten Jahren einige Studien veröffentlicht, welche die Behandlung des frühen und fortgeschrittenen Mammakarzinoms deutlich verändert haben. Dies bedeutet jedoch nicht, dass die Meinungen aller Experten bei speziellen Fragen übereinstimmen. Gerade die Diversität bezüglich der Interpretation der Leitlinien und Studienergebnisse reflektiert die sich ständig ändernde Datenlage und ihre Komplexität sowie die Verfügbarkeit von neuen Medikamenten. Für die Therapie von Patientinnen mit frühen Stadien des Mammakarzinoms sind in den letzten Jahren neue Substanzen wie Pertuzumab, T‑DM1, Neratinib, Capecitabin und weitere hinzugekommen. Des Weiteren gibt es erste Ergebnisse zum Einsatz von CDK4/6-Inhibitoren in der adjuvanten Situation. Nicht zuletzt wird nach wie vor diskutiert, wie Multigentests eingesetzt werden können, um den Einsatz von Chemotherapien bei bestimmten Patientinnen vermeiden zu können. Diese Übersichtsarbeit fasst den Datenstand zusammen und veröffentlich die Abstimmungsergebnisse der St.‑Gallen-Brustkrebskonferenz 2021 zum Mammakarzinom in frühen Krankheitsstadien.

Abstract

The continuous availability of findings from new studies repeatedly results in updated treatment recommendations and guidelines. In the case of breast carcinoma in particular, several studies have been published in the last few years that have transformed how early and advanced breast carcinoma is being treated. However, this by no means means implies that there is agreement among all experts on specific issues. It is precisely the diversity of interpretation of guidelines and study findings that reflects the constantly changing available data and its complexity, as well as the availability of new drugs. In recent years, new substances such as pertuzumab, T‑DM1, neratinib and capecitabine have become available to treat patients with early stages of breast carcinoma. Furthermore, the first results on the use of CDK4/6 inhibitors for adjuvant treatment have now been published. Last but not least, the use of multigene tests to avoid the necessity of chemotherapy in certain patients is still under discussion. This review summarises the state of the data and publishes the results of the survey completed by experts at the 2021 St. Gallen Breast Cancer Conference on early-stage breast cancer.

Schlüsselwörter

frühe Brustkrebsstadien - Therapieentscheidungen - Expertenpanel

Key words

early breast cancer - therapy decisions - expert panel

Volltext

Referenzen

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