Triglyceride-Glucose Index and the Risk of Stroke: A Systematic
                    Review and Dose-Response Meta-Analysis

Xiao Feng; Yao Yao; Lingshan Wu; Chang Cheng; Qiaoqiao Tang; Shabei Xu

doi:10.1055/a-1766-0202

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2022; 54(03): 175-186
DOI: 10.1055/a-1766-0202

Endocrine Care

Triglyceride-Glucose Index and the Risk of Stroke: A Systematic Review and Dose-Response Meta-Analysis

Autoren

Xiao Feng

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China
Yao Yao

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China
Lingshan Wu

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China
Chang Cheng

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China
Qiaoqiao Tang

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China
Shabei Xu

¹Department of Neurology, Huazhong University of Science and Technology, Wuhan, China

Abstract

Insulin resistance (IR) is an independent risk factor of cardiovascular disease. Recent research has proposed a new inexpensive and reliable indicator of IR: triglyceride glucose index (TyG index). We aim to evaluate the dose-response association between the TyG index and stroke through meta-analysis. Literature published from inception until October 2021 were searched in PubMed, Embase, Cochrane Library and Web of science. Cohort studies published in English and focusing on the association between the TyG index and stroke were included in our meta-analysis. I² statistic and Chi-square were used to assess the heterogeneity. When I²≥30% or p≤0.10, the random-effect model was used to pool the effect; otherwise, we chose the fixed-effect model. Eleven cohort studies, including 5 721 077 subjects and 95 490 stroke patients, were included in our study. After pooling the effect adjusted by multiple confounders, we found that compared with the lowest baseline TyG index group, the highest one was independently associated with increased stroke risk (RR: 1.27; 95% CI, 1.24 to 1.29; I²=6%). Dose-response meta-analysis showed that the association between the two variables had a non-linear trend (p-nonlinearity<0.0001; p-heterogeneity=0.28). Subgroup analysis showed that the risk of ischemic stroke was positively correlated with TyG index (RR: 1.48; 95% CI, 1.34 to 1.62; I²=15%), while we did not observe this correlation in hemorrhagic stroke patients. In patients with type 2 diabetes and acute coronary syndrome, the TyG index was linearly correlated with incident strokes. In conclusion, elevated TyG index is the independent risk factor for incident strokes (especially ischemic stroke).

Key words

triglyceride-glucose index - insulin resistance - stroke - meta-analysis

Volltext

Referenzen

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