Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C–H Activation

Shuran Xu; Cankun Luo; Kaichuan Yan; Jianglian Li; Ruizhi Lai; Li Hai; Mei Guan; Yong Wu

doi:10.1055/a-1780-1935

Synthesis, Inhaltsverzeichnis

Synthesis 2022; 54(13): 3015-3024
DOI: 10.1055/a-1780-1935

paper

Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C–H Activation

Autoren

Shuran Xu

^aWest China Hospital, Sichuan University, Chengdu, 610041, P. R. of China

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Cankun Luo

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Kaichuan Yan

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Jianglian Li

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Ruizhi Lai

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Li Hai

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China
Mei Guan∗

^aWest China Hospital, Sichuan University, Chengdu, 610041, P. R. of China
Yong Wu∗

^bKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, P. R. of China

Abstract

Alle Artikel dieser Rubrik

Abstract

An iridium-catalyzed reaction protocol has been developed to achieve the oxidative C–H/N–H annulation of benzamides with cyclopropanols as C1 synthon. Structurally diverse isoindolin-1-ones were furnished via sequential C–H/C–C cleavage and C–C/C–N bond formation.

Key words

C–H activation - benzamides - cyclopropanols - C–N bond formation - isoindolin-1-ones

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References

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