Gram-Scale Synthesis of Substituted Triarylmethanes

Meng-Yang Chang; Chun-Yi Lin; Shin-Mei Chen

doi:10.1055/a-1863-3443

Synthesis, Table of Contents

Synthesis 2022; 54(20): 4561-4575
DOI: 10.1055/a-1863-3443

paper

Gram-Scale Synthesis of Substituted Triarylmethanes

Authors

Meng-Yang Chang ∗

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan

^bDepartment of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Chun-Yi Lin

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Shin-Mei Chen

^aDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Abstract

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Abstract

A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) is described via silica-coated magnetic nanoparticles of modified polyphosphoric acid (NiFe₂O₄@SiO₂-PPA)-mediated intermolecular Friedel–Crafts reaction of substituted aryl aldehydes with 2 equivalents of oxygenated arenes under environmentally friendly reaction conditions. Among the overall reaction process, only water was generated as the by-product. Various reaction conditions are investigated for efficient transformation.

Key words

gram-scale synthesis - triarylmethanes - magnetic nanoparticles - Friedel–Crafts reaction - environmentally friendly

Full Text

References

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Supplementary Material

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