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Synthesis 2022; 54(20): 4561-4575
DOI: 10.1055/a-1863-3443
DOI: 10.1055/a-1863-3443
paper
Gram-Scale Synthesis of Substituted Triarylmethanes
Authors
The authors would like to thank the Ministry of Science and Technology of the Republic of China (Taiwan) for the financial support (MOST 109-2113-M-037-014-MY3).
Abstract
A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) is described via silica-coated magnetic nanoparticles of modified polyphosphoric acid (NiFe2O4@SiO2-PPA)-mediated intermolecular Friedel–Crafts reaction of substituted aryl aldehydes with 2 equivalents of oxygenated arenes under environmentally friendly reaction conditions. Among the overall reaction process, only water was generated as the by-product. Various reaction conditions are investigated for efficient transformation.
Key words
gram-scale synthesis - triarylmethanes - magnetic nanoparticles - Friedel–Crafts reaction - environmentally friendlySupporting Information
- Scanned photocopies of NMR spectral data for all compounds and X-ray analysis data
of 4e and 4ah-1. Supporting information for this article is available online at https://doi.org/10.1055/a-1863-3443.
- Supporting Information (PDF)
Publication History
Received: 26 April 2022
Accepted after revision: 27 May 2022
Accepted Manuscript online:
27 May 2022
Article published online:
21 July 2022
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