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CC BY-NC-ND 4.0 · J Neurol Surg Rep 2022; 83(03): e83-e86
DOI: 10.1055/a-1871-3586
Skull Base Oncology Case Series

Sinonasal Undifferentiated Carcinoma with Failed Response to Induction Chemotherapy

Michael R. Papazian
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Alex J. Gordon
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Michael Chow
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Aneek Patel 
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Donato Pacione
2   Department of Neurosurgery, NYU Langone Medical Center, New York, New York, United States
,
Seth Lieberman
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
,
Babak Givi 
1   Department of Otolaryngology—Head and Neck Surgery, NYU Langone Medical Center, New York, New York, United States
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Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rapidly growing malignancy with a propensity for extensive local invasion. Multimodal therapy, including surgery, radiotherapy, and chemotherapy, is the standard approach to treatment, but the optimal sequence and combination of these modalities are uncertain. Induction chemotherapy is being increasingly utilized based on recent reports that show better outcomes for patients who respond to chemotherapy and the ability to determine further course of treatment. We present a unique case of a patient with locally advanced SNUC that did not respond to induction chemotherapy and a review of the available literature relating to the management of this rare malignancy.

Keywords

sinonasal undifferentiated carcinoma - induction chemotherapy - endoscopic craniofacial resection - review


Publikationsverlauf

Eingereicht: 14. April 2022

Angenommen: 02. Juni 2022

Accepted Manuscript online:
08. Juni 2022

Artikel online veröffentlicht:
10. Juli 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Gamez ME, Lal D, Halyard MY. et al. Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience. Head Neck 2017; 39 (09) 1819-1824
    CrossrefPubMedGoogle Scholar
  • 2 Perri F, Della Vittoria Scarpati G, Ionna F. et al. Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature. Anticancer Drugs 2019; 30 (03) 308-312
    CrossrefPubMedGoogle Scholar
  • 3 Amit M, Abdelmeguid AS, Watcherporn T. et al. Induction chemotherapy response as a guide for treatment optimization in sinonasal undifferentiated carcinoma. J Clin Oncol 2019; 37 (06) 504-512
    CrossrefPubMedGoogle Scholar
  • 4 Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F. Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase. J Neurooncol 2020; 150 (03) 367-375
    CrossrefPubMedGoogle Scholar
  • 5 Morand GB, Anderegg N, Vital D. et al. Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): a case-series, systematic review and meta-analysis. Oral Oncol 2017; 75: 28-34
    CrossrefPubMedGoogle Scholar
  • 6 Chambers KJ, Lehmann AE, Remenschneider A. et al. Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. J Neurol Surg B Skull Base 2015; 76 (02) 94-100
    PubMedGoogle Scholar
  • 7 Mendenhall WM, Mendenhall CM, Riggs Jr CE, Villaret DB, Mendenhall NP. Sinonasal undifferentiated carcinoma. Am J Clin Oncol 2006; 29 (01) 27-31
    CrossrefPubMedGoogle Scholar
  • 8 Khan MN, Konuthula N, Parasher A. et al. Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. Int Forum Allergy Rhinol 2017; 7 (02) 205-210
    CrossrefPubMedGoogle Scholar
  • 9 de Bonnecaze G, Verillaud B, Chaltiel L. et al. Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study. Int Forum Allergy Rhinol 2018; 8 (09) 1065-1072
    CrossrefPubMedGoogle Scholar
  • 10 Reiersen DA, Pahilan ME, Devaiah AK. Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. Otolaryngol Head Neck Surg 2012; 147 (01) 7-14
    CrossrefPubMedGoogle Scholar
  • 11 Gray ST, Herr MW, Sethi RK. et al. Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review. Head Neck 2015; 37 (03) 366-374
    CrossrefPubMedGoogle Scholar
  • 12 Eloy JA, Vivero RJ, Hoang K. et al. Comparison of transnasal endoscopic and open craniofacial resection for malignant tumors of the anterior skull base. Laryngoscope 2009; 119 (05) 834-840
    CrossrefPubMedGoogle Scholar
  • 13 Revenaugh PC, Seth R, Pavlovich JB, Knott PD, Batra PS. Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. Am J Otolaryngol 2011; 32 (06) 464-469
    CrossrefPubMedGoogle Scholar
  • 14 Faisal M, Seemann R, Lill C. et al. Elective neck treatment in sinonasal undifferentiated carcinoma: systematic review and meta-analysis. Head Neck 2020; 42 (05) 1057-1066
    CrossrefPubMedGoogle Scholar