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CC BY-NC-ND 4.0 · Organic Materials 2022; 4(03): 53-60
DOI: 10.1055/a-1881-0385
Supramolecular Chemistry
Short Review

Dynamically Self-Assembled Supramolecular Probes in Liposomes

Andreas Hennig 
a   Center for Cellular Nanoanalytics (CellNanOs) and Department of Biology and Chemistry, Universität Osnabrück, Barbarastraße 7, 49069 Osnabrück, Germany.
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Abstract

Liposomes are artificial vesicles, in which an aqueous inner compartment is separated from its environment by a phospholipid membrane. They have been extensively studied as cell membrane models and offer the possibility to confine molecules and chemical reactions to a small sub-micrometer-sized volume. This short review provides an overview of liposome-encapsulated, dynamically self-assembled, supramolecular structures, in which the assembly and disassembly of the supramolecular structures can be followed by optical spectroscopic methods. This includes self-quenched fluorescent dyes and dye/quencher pairs, helical stacks of guanosine nucleotides, dynamic covalent boronate esters, and supramolecular host–guest complexes. The resulting liposomes are typically used to study membrane transport processes, but the results summarized herein also serve as a potential blueprint for studying dynamic self-assembly in confined spaces by optical spectroscopic methods.

Table of content:

1 Introduction

2 Probes Based on Fluorescence Quenching

3 Chirogenic G-Quartet Probes

4 Chromogenic Probes Using Dynamic Covalent Bonds

5 Self-Assembled Host–Dye Reporter Pairs

6 Conclusions and Outlook

Key words

self-assembly - host–guest chemistry - liposomes - fluorescence - circular dichroism


Publication History

Received: 30 May 2022

Accepted after revision: 21 June 2022

Accepted Manuscript online:
21 June 2022

Article published online:
27 July 2022

© 2022. The authors. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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