Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in
                    Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and
                    Gestational Hypertension

Filiz Yarsilikal Guleroglu; Esra Selvi; Isil Turan Bakirci; Olgu Bafalı; Hatice Argun Atalmis; Merve Yasti Dayan; Aliye Balkan Ozmen; Nazan Yurtcu; Busra Seker Atas; Esma Ozdemir Anayurt; Ali Cetin

doi:10.1055/a-1937-1155

Zeitschrift für Geburtshilfe und Neonatologie, Inhaltsverzeichnis

Z Geburtshilfe Neonatol 2023; 227(01): 42-50
DOI: 10.1055/a-1937-1155

Original Article

Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension

Filiz Yarsilikal Guleroglu

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Esra Selvi

²Department of Obstetrics and Gynecology, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkey

,

Isil Turan Bakirci

³Department of Obstetrics and Gynecology, Bursa City Hospital, Bursa, Turkey

,

Olgu Bafalı

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Hatice Argun Atalmis

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Merve Yasti Dayan

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Aliye Balkan Ozmen

⁴Department of Obstetrics and Gynecology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey

,

Nazan Yurtcu

⁵Department of Biochemistry, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Busra Seker Atas

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Esma Ozdemir Anayurt

⁵Department of Biochemistry, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

,

Ali Cetin

¹Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences University, Istanbul, Turkey

› Institutsangaben

Abstract

Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).

Methods This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI≥30 kg/m²; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA.

ResultsObesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully.

Conclusions Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy.

Keywords

Pregnancy - obesity - diabetes mellitus - gestational hypertension - biomarker

Volltext

Referenzen

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