Abstract
Background Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory
effects of intraparenchymal hemorrhage (ICH) are responsible for the highly detrimental
effects on brain tissue. Oxidative stress also plays a significant role in brain damage
after ICH; however, it is less important than other factors. In this study, we aimed
to evaluate the oxidative stress parameters malondialdehyde (MDA) and antioxidant-reduced
glutathione (GSH), superoxide dismutase (SOD), and catalase (CT) activities in operated
and nonoperated patients with spontaneous ICH.
Methods One hundred patients with spontaneous ICH and 100 healthy controls were included
in this study. Within the indication, 50 of the 100 patients underwent decompressive
surgery. MDA, GSH, SOD, and CT activities were measured in the serum obtained from
the patients.
Results SOD and CT levels were lower in the nonoperated group than in the operated and control
groups. GSH was similar in the operated and nonoperated groups, but it was lower in
the control group. However, MDA was higher in those who did not undergo surgery than
in the other groups.
Conclusions In our study, MDA, an indicator of oxidative stress, was found to be lower, and CT
and SOD activities were found to be higher in ICH patients who underwent decompression
than in those who did not. This is the first study to present the correlations of
MDA, SOD, CT, and GSH in operated and nonoperated patients with spontaneous ICH.
Keywords
intracerebral hemorrhage - oxidative stress - superoxide dismutase - catalase - glutathione
- malondialdehyde
