Androgens’ Role in Severity and Mortality Rates of
                    COVID-19

Ali Ataei; Mohammad Moein Derakhshan; Mohadese Razmjooie; Fateme Zare; Habibe Amiresmaeili; Negin Salehi; Negar Namakkoobi; Hamid Mirhosseini; Bardia Karim; Sima Iravani

doi:10.1055/a-1954-5605

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2022; 54(12): 813-826
DOI: 10.1055/a-1954-5605

Review

Androgens’ Role in Severity and Mortality Rates of COVID-19

Authors

Ali Ataei

¹School of Medicine, Bam University of Medical Sciences, Bam, Iran
Mohammad Moein Derakhshan

²Student Research Committee, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Mohadese Razmjooie

³Nursing School, Islamic Azad University of Darab, Darab, Iran
Fateme Zare

⁴Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Habibe Amiresmaeili

⁵Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran
Negin Salehi

⁶School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Negar Namakkoobi

⁷Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Hamid Mirhosseini

⁸Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Bardia Karim

⁹Student Research Committee, Babol University of Medical Science, Babol, Iran
Sima Iravani

¹⁰School of Paramedical Sciences, Yazd University of Medical Science, Yazd, Iran

Abstract

By the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. This review aimed to assess the role of androgens in COVID-19 severity and mortality. Androgens increase expressions of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2), which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) were substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor drugs considerably modified COVID-19 symptoms. Androgen deprivation therapy also improved COVID-19 symptoms in prostate cancer: overall the role of androgens in severity of COVID-19 and its associated mortality seemed to be very important. So, more studies in variety of populations are required to define the absolute role of androgens.

Key words

androgens - testosterone - COVID-19 severity - SARS-CoV-2 - TMPRSS2 - cytokine storm

Volltext

Referenzen

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