Die nichtalkoholische Steatohepatitis (NASH) als Ursache erhöhter Leberwerte

Die nichtalkoholische Steatohepatitis (NASH) ist die progrediente Verlaufsform der nichtalkoholischen Fettlebererkrankung (NAFLD) und durch eine erhöhte entzündliche Aktivität gekennzeichnet, die in einer Leberfibrose bzw. Leberzirrhose resultieren kann. NASH-Aktivität und Leberfibrose sind die prognoserelevanten Risikofaktoren, sodass eine rationale Stufendiagnostik, Identifikation von Risikopersonen und ein zielgerichteter Einsatz der therapeutischen Möglichkeiten entscheidend ist.

Abstract

Non-alcoholic steatohepatitis (NASH) is the progressive entity of non-alcoholic fatty liver disease (NAFLD) and characterised by increased inflammatory activity, potentially resulting in liver fibrosis and ultimately cirrhosis. NASH activity and hepatic fibrosis are the prognosis determinating risk factors – rational stepwise diagnostic approaches are urgently needed as therapeutic options beyond lifestyle modifications are limited.

Schlüsselwörter

nichtalkoholische Fettlebererkrankung (NAFLD) - nichtalkoholische Steatohepatitis (NASH) - Leberfibrose - Risikostratifikation - nicht invasive Diagnostik

Keywords

Non-alcoholic fatty liver disease (NAFLD) - non-alcoholic steatohepatitis (NASH) - liver fibrosis - risk stratification - non-invasive diagnostics

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