Schwere Komplikationen bei Lebendimpfungen

Florian Gothe

doi:10.1055/a-2060-3412

Kinder- und Jugendmedizin, Table of Contents

Kinder- und Jugendmedizin 2023; 23(03): 159-164
DOI: 10.1055/a-2060-3412

Schwerpunkt

Schwere Komplikationen bei Lebendimpfungen

Was uns Kinder mit seltenen Immundefekterkrankungen über antivirale Immunität lehrenSevere complications following live-viral vaccinationWhat rare inborn errors of immunity can teach us about human antiviral immunity

Florian Gothe∗

¹Dr. von Haunersches Kinderspital, München

› Author Affiliations

Abstract

ZUSAMMENFASSUNG

Lebendimpfstoffe erzeugen eine starke, lang-anhaltende Immunität und haben Millionen Menschenleben weltweit gerettet. Sehr selten jedoch können sich angeborene Störungen des Immunsystems nach einer Lebendimpfung manifestieren. Im vorliegenden Beitrag sollen anhand monogenetischer Immundefekte entscheidende Mechanismen der antiviralen Immunität diskutiert werden. Das Verständnis der jeweiligen pathophysiologischen Grundlagen erlaubt Rückschlüsse beispielsweise auf die Impfstoffentwicklung.

ABSTRACT

Live-viral vaccinations constitute strong and durable immune responses and have saved millions of lives worldwide. However, in rare circumstances, inborn errors of immunity can manifest following live-viral vaccination. This article discusses important mechanism of human antiviral immunity highlighted by monogenic immune deficiency states. Understanding the pathomechanistic basis of these rare defects might help improving live-viral vaccine efficiency and safety.

Schlüsselwörter

Lebendimpfung - angeborener Immundefekt - antivirale Immunität - Typ-I-Interferon

Keywords

Live-viral vaccine - inborn error of immunity - antiviral immunity - type I interferon

Full Text

References

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