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Exp Clin Endocrinol Diabetes 2023; 131(07/08): 394-401
DOI: 10.1055/a-2066-2696
DOI: 10.1055/a-2066-2696
Review
Primary Aldosteronism Prevalence – An Unfolding Story
Abstract
Primary aldosteronism (PA) is characterized by dysregulated, renin-independent aldosterone excess. Long perceived as rare, PA has emerged as one of the most common causes of secondary hypertension. Failure to recognize and treat PA results in cardiovascular and renal complications, through processes mediated by both direct target tissue insults and indirectly, by hypertension. PA spans a continuum of dysregulated aldosterone secretion, which is typically recognized in late stages after treatment-resistant hypertension and cardiovascular and/or renal complications develop. Determining the precise disease burden remains challenging due to heterogeneity in testing, arbitrary thresholds, and populations studied. This review summarizes the reports on PA prevalence among the general population and in specific high-risk subgroups, highlighting the impact of rigid versus permissive criteria on PA prevalence perception.
Publication History
Received: 30 January 2023
Received: 09 March 2023
Accepted: 27 March 2023
Accepted Manuscript online:
30 March 2023
Article published online:
31 May 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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