The Genetic Association with Athlete Status, Physical Performance,
                    and Injury Risk in Soccer

Conall F. Murtagh; Elliott C. R. Hall; Thomas E. Brownlee; Barry Drust; Alun G. Williams; Robert M. Erskine

doi:10.1055/a-2103-0165

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2023; 44(13): 941-960
DOI: 10.1055/a-2103-0165

Review

The Genetic Association with Athlete Status, Physical Performance, and Injury Risk in Soccer

Conall F. Murtagh

¹School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

²Sports Science Department, Liverpool Football Club and Athletic Grounds Ltd, Liverpool, United Kingdom

,

Elliott C. R. Hall

¹School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

³Faculty of Health Sciences and Sport, University of Stirling, Stirling, United Kingdom

,

Thomas E. Brownlee

⁴School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom

,

Barry Drust

⁴School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom

,

Alun G. Williams

⁵Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom

⁶Institute of Sport, Exercise and Health, University College London, London, United Kingdom

,

Robert M. Erskine

¹School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

⁶Institute of Sport, Exercise and Health, University College London, London, United Kingdom

› Institutsangaben

Abstract

The aim of this review was to critically appraise the literature concerning the genetic association with athlete status, physical performance, and injury risk in soccer. The objectives were to provide guidance on which genetic markers could potentially be used as part of future practice in soccer and to provide direction for future research in this area. The most compelling evidence identified six genetic polymorphisms to be associated with soccer athlete status (ACE I/D; ACTN3 rs1815739; AGT rs699; MCT1 rs1049434; NOS3 rs2070744; PPARA rs4253778), six with physical performance (ACTN3 rs1815739; AMPD1 rs17602729; BDNF rs6265; COL2A1 rs2070739; COL5A1 rs12722; NOS3 rs2070744), and seven with injury risk (ACTN3 rs1815739; CCL2 rs2857656; COL1A1 rs1800012; COL5A1 rs12722; EMILIN1 rs2289360; IL6 rs1800795; MMP3 rs679620). As well as replication by independent groups, large-scale genome-wide association studies are required to identify new genetic markers. Future research should also investigate the physiological mechanisms associating these polymorphisms with specific phenotypes. Further, researchers should investigate the above associations in female and non-Caucasian soccer players, as almost all published studies have recruited male participants of European ancestry. Only after robust, independently replicated genetic data have been generated, can genetic testing be considered an additional tool to potentially inform future practice in soccer.

Key words

SNP - polymorphism - DNA - injuries - football - physical performance

Volltext

Referenzen

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