Abstract
Osteoarthritis is a common chronic degenerative disease, of which the essence is
the degenerative changes of bone and joint cartilage, involving damage in
multiple structures such as bone, synovium and joints. In the mechanism of
arthritis inflammation is closely related, and therefore the exploration to
inhibit inflammatory mediators is crucial for the clinical prevention and
treatment of osteoarthritis. Inotodiol is a lanostane triterpenoid isolated from
Inonotus obliquus, which had been extensively reported to be an
anti-inflammatory agent, but its effect on arthritis remains unknown. In this
study, we firstly demonstrated that inotodiol significantly reduced
IL-1β-induced chondrocyte injury and inhibited the release of
inflammatory factors. At the same time, experiments in vivo showed that
inotodiol could effectively improve the symptoms of joint injury in mice and
reduce the area of cartilage destruction, indicating that inotodiol may be a
potential therapeutic drug for osteoarthritis.
Key words
osteoarthritis - inflammation - inotodiol - chondrocyte injury
