Update Breast Cancer 2024 Part 1 – Expert Opinion on
                    Advanced Breast Cancer

Rachel Würstlein; Hans-Christian Kolberg; Andreas D. Hartkopf; Tanja N. Fehm; Manfred Welslau; Florian Schütz; Peter A. Fasching; Wolfgang Janni; Isabell Witzel; Christoph Thomssen; Annika Krückel; Erik Belleville; Diana Lüftner; Michael Untch; Marc Thill; Manuel Hörner; Hans Tesch; Nina Ditsch; Michael P. Lux; Bahriye Aktas; Maggie Banys-Paluchowski; Florin-Andrei Taran; Achim Wöckel; Nadia Harbeck; Elmar Stickeler; Rupert Bartsch; Andreas Schneeweiss; Johannes Ettl; David Krug; Volkmar Müller

doi:10.1055/a-2300-5326

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2024; 84(06): 529-540
DOI: 10.1055/a-2300-5326

GebFra Science

Review/Übersicht

Update Breast Cancer 2024 Part 1 – Expert Opinion on Advanced Breast Cancer

Article in several languages: English | deutsch

Authors

Rachel Würstlein

¹Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany
Hans-Christian Kolberg

²Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
Andreas D. Hartkopf

³Department of Gynecology and Obstetrics, Tübingen University Hospital, Tübingen, Germany
Tanja N. Fehm

⁴Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf) Germany
Manfred Welslau

⁵Onkologie Aschaffenburg, Aschaffenburg, Germany
Florian Schütz

⁶Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany
Peter A. Fasching

⁷Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Wolfgang Janni

⁸Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
Isabell Witzel

⁹Universitätsspital Zürich, Klinik für Gynäkologie, Zürich, Switzerland
Christoph Thomssen

¹⁰Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Annika Krückel

⁷Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Erik Belleville

¹¹ClinSol GmbH & Co. KG, Würzburg, Germany
Diana Lüftner

¹²Immanuel Hospital Märkische Schweiz, Buckow, Germany & Medical University of Brandenburg Theodor-Fontane, Rüdersdorf, Germany
Michael Untch

¹³Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany
Marc Thill

¹⁴Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany
Manuel Hörner

⁷Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Hans Tesch

¹⁵Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany
Nina Ditsch

¹⁶Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany
Michael P. Lux

¹⁷Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany
Bahriye Aktas

¹⁸Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany
Maggie Banys-Paluchowski

¹⁹Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Florin-Andrei Taran

²⁰Department of Gynecology and Obstetrics, University Hospital Freiburg, Freiburg, Germany
Achim Wöckel

²¹Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
Nadia Harbeck

¹Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany
Elmar Stickeler

²²Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany
Rupert Bartsch

²³Medical University of Vienna, Department of Medicine I, Division of Oncology, Vienna, Austria
Andreas Schneeweiss

²⁴National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany
Johannes Ettl

²⁵Klinikum Kempten, Klinikverbund Allgäu, Klinik für Frauenheilkunde und Gynäkologie, Kempten, Germany
David Krug

²⁶Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Strahlentherapie, Kiel, Germany
Volkmar Müller

²⁷Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

Abstract

Clinical evidence is interpreted based on clinical studies and personal experience which can lead to different interpretations of data. This makes the opinions issued by panels of experts such as the Advanced Breast Cancer Panel which convened in November 2023 for the seventh time (ABC7) particularly important. At the conference, current issues around advanced breast cancer were evaluated by an international team of experts.

In 2023 the data on CDK4/6 inhibitors was so extensive that the answers to questions about the sequencing of therapy and the potential use of chemotherapy as an alternative therapy were relatively clear. Moreover, data on antibody drug conjugates which provides a good overview of their uses is available for all molecular subtypes.

Some therapeutic settings, including patients with brain metastases or leptomeningeal disease, older patients, locally advanced breast cancer and visceral crises, continue to be particularly important and were discussed in structured sessions. The scientific context of some of the topics discussed at ABC7 is presented and assessed here.

Keywords

breast cancer - metastatic - endocrine therapy - antibody drug conjugate - chemotherapy

Full Text

References

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