Zirkadiane Medizin – wie relevant ist sie in der Intensivmedizin?

Die zirkadiane Intensivmedizin ist ein neues Forschungsgebiet, das sich der Pathophysiologie und den Auswirkungen gestörter zirkadianer Rhythmen auf den Krankheitsverlauf kritisch Kranker widmet – z. B. dem Auftreten von Delir oder von Blutdruckveränderungen. Dieser Artikel präsentiert Konzepte und Interventionen der zirkadianen Intensivmedizin, die zukünftig einen neuen therapeutischen Horizont bei Intensivpatient*innen darstellen könnten.

Abstract

Circadian intensive care medicine is a new field of research that investigates the pathophysiological mechanisms and clinical impact of disrupted circadian rhythms on the course of disease in critically ill patients. Initial studies have demonstrated rhythm disturbances at the clinical, hormonal and molecular level. These disturbances are often characterized by a loss of rhythmicity, for example reflected in reduced fluctuations of blood pressure within a 24-hour cycle. The loss of such rhythmicity has been associated with increased mortality rates. Moreover, circadian dysrhythmia is linked to several severe complications, including delirium. This article presents concepts and interventions in circadian intensive care medicine that may represent a new therapeutic horizon for critically ill patients in the future.

Schlüsselwörter

zirkadiane Intensivmedizin - zirkadiane Dysrhythmie - Delir - Schlafstörungen - Interventionsmöglichkeiten - intervention options

Keywords

circadian intensive care medicine - circadian dysrhythmia - delirium - sleep disorders

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