Molekulare PET-Diagnostik inflammatorischer und fibrotischer Prozesse nach akutem Myokardinfarkt

Zusammenfassung

Nach akutem Myokardinfarkt entscheidet die frühe Gewebsreaktion – insbesondere die Interaktion zwischen Immunzellen und Fibroblasten – maßgeblich über das Risiko für ventrikuläres Remodeling und chronische Herzinsuffizienz. Während Standardtherapien wie RAAS-Blockade und Betablocker vorrangig in der chronischen Phase greifen, eröffnet das subakute Zeitfenster nach einem Infarkt die Möglichkeit gezielter, personalisierter Interventionen. Molekulare Bildgebung mit Radiotracern erlaubt die nicht-invasive Darstellung dieser biologischen Prozesse und kann helfen, Patienten zu identifizieren, die am ehesten von neuen antiinflammatorischen oder antifibrotischen Therapien profitieren. Der Artikel gibt einen Überblick über den klinischen Hintergrund, zentrale pathophysiologische Mechanismen und aktuelle Entwicklungen in der PET-Bildgebung bei Myokardinfarkt.

Abstract

After acute myocardial infarction, the early tissue response – in particular the interaction between immune cells and fibroblasts – has a decisive influence on the risk of ventricular remodeling and chronic heart failure. While standard therapies such as RAAS blockade and beta blockers are primarily effective in the chronic phase, the subacute window of opportunity after an infarction opens up the possibility of targeted, personalized interventions. Molecular imaging with radiotracers allows non-invasive visualization of these biological processes and can help identify patients who are most likely to benefit from new anti-inflammatory or anti-fibrotic therapies. This article provides an overview of the clinical background, key pathophysiological mechanisms, and current developments in PET imaging for myocardial infarction.

Schlüsselwörter

PET-Diagnostik - Myokardinfarkt - Remodeling

Keywords

PET diagnostics - myocardial infarction - remodeling

Publication History

Article published online:
08 December 2025

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