A 65-year-old man, who denied a smoking history, presented with chest distress and
pain persisting for over a week. A contrast-enhanced chest CT scan revealed a large
irregular mass in the right thoracic cavity with heterogeneous enhancement. The 18F-FDG
PET/CT showed a large mass in the right thoracic cavity with heterogeneous markedly
high FDG uptake. The patient subsequently underwent a bronchoscopic-guided mucosal
biopsy at the opening of the right upper lobe. The histological and immunohistochemical
findings were consistent with thoracic SMARCA4-deficient undifferentiated tumor.
Keywords
SMARCA4 - thoracic SMARCA4-deficient undifferentiated tumor - 18F-FDG - PET/CT