Abstract
The stereoselective synthesis of β-amino acids has attracted major attention among
the synthetic community in recent years. This review provides an overview of the important
advances in chiral β-amino acid synthesis over the past decade. It covers the development
of enantioselective methods using transition-metal complexes or organocatalysts, mainly
including catalytic asymmetric hydrogenation, the Mannich reaction, multicomponent
reactions of diazo compounds, and conjugate addition. Additionally, the asymmetric
synthesis of optically active β-amino acids by other approaches are also summarized.
1 Introduction
2 Strategies towards the Asymmetric Synthesis of β-Amino Acids
2.1 Hydrogenation
2.2 Mannich Reaction
2.3 Conjugate Addition
2.4 Multicomponent Reactions
2.5 Miscellaneous
2.5.1 Synthesis of β-Amino Acids from Chiral Amines
2.5.2 Synthesis of β-Amino Acids from Isoxazolidinones
2.5.3 Synthesis of β-Amino Acids by Other Methodologies
3 Summary and Outlook
Key words
asymmetric synthesis - β-amino acids - transition-metal catalysis - organocatalysis
- chiral ligands
