Abstract
In recent years, the incidence of neurodegenerative diseases, including Alzheimerʼs
disease, Parkinsonʼs disease, Huntingtonʼs disease, and amyotrophic lateral sclerosis,
has exhibited a steadily rising trend, which has posed a major challenge to the global
public health. Traditional Chinese medicine, with its multicomponent and multitarget
characteristics, offers a promising approach to treating neurodegenerative diseases.
However, comprehensively elucidating the complex mechanisms underlying traditional
Chinese medicine formulations remains challenging. As an emerging systems biology
method, network pharmacology has provided a vital tool for revealing the multitarget
mechanisms of traditional Chinese medicine through high-throughput technologies, molecular
docking, and network analysis. This paper reviews the advancements in the application
of network pharmacology in treating neurodegenerative diseases using traditional Chinese
medicine, analyzes the current status of
relevant databases and technological methods, discusses the limitations, and proposes
future directions to promote the modernization of traditional Chinese medicine and
the development of precision medicine.
Keywords
neurodegenerative diseases - traditional Chinese medicine - network pharmacology -
therapeutic targets
