Assessment of the Haemostatic Potential of Platelets Readied for Transfusion

Unwana Emagha; Khawla Yousif; Michelle Duff; Edwina Geraghty; Janice O'Shaughnessy; Philip Murphy; Stefano Verardi; Stephen Marcella; Roy Bentley; Dermot Cox

doi:10.1055/a-2525-6768

TH Open, Table of Contents

CC BY-NC-ND 4.0 · TH Open 2025; 09: a25256768
DOI: 10.1055/a-2525-6768

Letter to the Editor

Assessment of the Haemostatic Potential of Platelets Readied for Transfusion

Authors

Unwana Emagha

¹School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
Khawla Yousif

¹School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
Michelle Duff

¹School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
Edwina Geraghty

¹School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
Janice O'Shaughnessy

²Department of Haematology, Beaumont Hospital, Dublin, Ireland
Philip Murphy

²Department of Haematology, Beaumont Hospital, Dublin, Ireland
Stefano Verardi

³BV Medical Affairs, Shionogi BV, Amsterdam, Netherlands
Stephen Marcella

⁴Global EPI and RWE, Shionogi Inc., Florham Park, New Jersey
Roy Bentley

⁵Global Scientific Operations for Bentley, Shionogi Inc., Florham Park, New Jersey
Dermot Cox

¹School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

Abstract

Bibliographical Record
Unwana Emagha, Khawla Yousif, Michelle Duff, Edwina Geraghty, Janice O'Shaughnessy, Philip Murphy, Stefano Verardi, Stephen Marcella, Roy Bentley, Dermot Cox. Assessment of the Haemostatic Potential of Platelets Readied for Transfusion. TH Open 2025; 09: a25256768.
DOI: 10.1055/a-2525-6768

Full Text

References

References
1 Banerjee S, Angiolillo DJ, Boden WE. et al. Use of antiplatelet therapy/DAPT for post-PCI patients undergoing noncardiac surgery. J Am Coll Cardiol 2017; 69 (14) 1861-1870
2 Shpigelman J, Proshkina A, Daly MJ, Cox D. Personalized dual antiplatelet therapy in acute coronary syndromes: striking a balance between bleeding and thrombosis. Curr Cardiol Rep 2023; 25 (07) 693-710
3 Taylor G, Osinski D, Thevenin A, Devys J-M. Is platelet transfusion efficient to restore platelet reactivity in patients who are responders to aspirin and/or clopidogrel before emergency surgery?. J Trauma Acute Care Surg 2013; 74 (05) 1367-1369
4 Cohn SM, Jimenez JC, Khoury L, Perez JM, Panzo M. Inability to reverse aspirin and clopidogrel-induced platelet dysfunction with platelet infusion. Cureus 2019; 11 (01) e3889
5 Nagalla S, Sarode R. Role of platelet transfusion in the reversal of anti-platelet therapy. Transfus Med Rev 2019; 33 (02) 92-97
6 van der Meer PF, de Korte D. Platelet additive solutions: a review of the latest developments and their clinical implications. Transfus Med Hemother 2018; 45 (02) 98-102
7 Offiah C. et al. Performance metrics of the AGGRESTAR PL-12 platelet function analyser in patients with TIA or ischaemic stroke on commonly-prescribed antiplatelet regimens. Thromb Haemost 2021; 5: 1057
8 Guan J, Cong Y, Ren J. et al. Comparison between a new platelet count drop method PL-11, light transmission aggregometry, VerifyNow aspirin system and thromboelastography for monitoring short-term aspirin effects in healthy individuals. Platelets 2015; 26 (01) 25-30
9 Ma L, Chen W, Pan Y. et al. Comparison of VerifyNow, thromboelastography, and PL-12 in patients with minor ischemic stroke or transient ischemic attack. Aging (Albany NY) 2021; 13 (06) 8396-8407
10 Yue C, Lin Z, Lu C, Chen H. Efficacy of monitoring platelet function by an automated PL-12 analyzer during the treatment of acute cerebral infarction with antiplatelet medicine. Clin Appl Thromb Hemost 2021; 27: 10 760296211001119
11 Caram-Deelder C, Kreuger AL, Jacobse J, van der Bom JG, Middelburg RA. Effect of platelet storage time on platelet measurements: a systematic review and meta-analyses. Vox Sang 2016; 111 (04) 374-382
12 Weisel JW, Litvinov RI. Red blood cells: the forgotten player in hemostasis and thrombosis. J Thromb Haemost 2019; 17 (02) 271-282
13 Zheng Y-Y, Wu TT, Yang Y. et al. Personalized antiplatelet therapy guided by a novel detection of platelet aggregation function in stable coronary artery disease patients undergoing percutaneous coronary intervention: a randomized controlled clinical trial. Eur Heart J Cardiovasc Pharmacother 2020; 6 (04) 211-221
14 Cornelissen LL, Caram-Deelder C, Meier RT, Zwaginga JJ, Evers D. Dutch Blood Transfusion Related Research Consortium. Platelet transfusion and tranexamic acid to prevent bleeding in outpatients with a hematological disease: a Dutch nationwide survey. Eur J Haematol 2021; 106 (03) 362-370