Constructing Figure-Eight Structures by Inner-Bond Cleavage

Abstract

Contemporary synthetic strategies in organic chemistry rely heavily on the stepwise formation of bonds between constituent fragments of the target compound, namely the bottom-up approach. However, this dependency poses significant challenges for the preparation of several classes of complex molecules, such as figure-eight molecules, despite their desirable functionality in advanced materials. Recently, we have developed an oxidative inner-bond-cleavage approach that enables a scalable, catalytic, and enantioselective synthesis of figure-eight aromatic macrocycles. This Synpacts article summarizes the background, results, and outlook of our achievement.

1 Introduction

2 Background

3 Our Contribution

4 Conclusion and Outlook

Key words

nonplanar π-systems - figure-eight molecules - inner-bond cleavage - asymmetric synthesis - circularly polarized luminescence

Publication History

Received: 09 January 2025

Accepted after revision: 30 January 2025

Accepted Manuscript online:
30 January 2025

Article published online:
17 March 2025

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