Abstract
Management of hemostasis in the perioperative setting, in trauma or in acute care,
has considerably changed over the last two decades. Viscoelastic testing and single-factor
replacement therapies have become cornerstones of the respective clinical approaches.
Here, we illuminate the basic theories for these approaches as well as the important
evidence available. Both viscoelastic assays and single-factor replacements are important
improvements; their use must be based on the strongest scientific evidence available.
Keywords
viscoelastic assays - factor concentrates - fibrinogen/fibrin - factor XIII/transglutaminases
- resuscitation
