Proteomic Profiling of Age-Related Proteins Following Extracorporeal
                    Apheresis

Romy Walther; Bhawana Singh; Xiaoke Yin; Philip Mavberg; Anna Mücke; Roman Rodionov; Mahmoud Babir; Manuel Mayr; Stefan R. Bornstein

doi:10.1055/a-2563-1187

Hormone and Metabolic Research, Table of Contents

Horm Metab Res
DOI: 10.1055/a-2563-1187

Original Article: Endocrine Care

Proteomic Profiling of Age-Related Proteins Following Extracorporeal Apheresis

Romy Walther

¹Department and Outpatient Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany (Ringgold ID: RIN39063)

,

Bhawana Singh

²National Heart and Lung Institute, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN4615)

,

Xiaoke Yin

²National Heart and Lung Institute, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN4615)

,

Philip Mavberg

³Ayus Medical Group, Basel, Switzerland

,

Anna Mücke

⁴INUSpheresis Center Basel, Ayus Medical Group, Basel, Switzerland

,

Roman Rodionov

¹Department and Outpatient Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany (Ringgold ID: RIN39063)

,

Mahmoud Babir

⁵Department of Cardiology, Harefield Hospital, Harefield, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN156725)

,

Manuel Mayr

²National Heart and Lung Institute, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN4615)

,

Stefan R. Bornstein

¹Department and Outpatient Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany (Ringgold ID: RIN39063)

› Author Affiliations

Abstract

Lipoprotein apheresis (LA) is often the last option to adequately reduce lipoproteins in patients with familial hypercholesterolemia and lipoprotein (a) hyperlipidemia. Characterized by mild side effects, it is now the most effective method of preventing major cardiovascular events (CVEs). This benefit is due not only to the lowering of lipoprotein levels, but probably also to many other pleiotropic effects that have been extensively described in the literature. These include the reduction of inflammatory signaling substances, fibrinogen, plasminogen or components of the oxidative stress response. Here, we performed a proteomic analysis of 12 patients treated with therapeutic apheresis using two different pore size filters to quantify the effect on age-related plasma proteins. This study showed that important proteins such as α-2-macroglobulin, apolipoprotein C-III, complement C1s subcomponent, C4b-binding protein alpha chain, CD5 antigen-like and pregnancy zone protein, whose role in numerous aging processes has been well described, were significantly reduced by apheresis treatment. We conclude that therapeutic apheresis may be a promising approach to reduce these age-related proteins and that these treatments may become an essential part of managing cardiovascular risk in an aging population.

Keywords

extracorporal apheresis - proteomic analysis - aging

Full Text

References

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