Iron-Catalyzed P(O)–S Bond Formation through Cross-Dehydrogenative Coupling of Thiols with P(O)H Compounds

Yuge Ji; Bing Han; Hongbin Liu; Di Song; Lei Liu; Gang Wang

doi:10.1055/a-2600-4572

Synthesis, Inhaltsverzeichnis

Synthesis 2025; 57(16): 2530-2538
DOI: 10.1055/a-2600-4572

paper

Iron-Catalyzed P(O)–S Bond Formation through Cross-Dehydrogenative Coupling of Thiols with P(O)H Compounds

Autor*innen

Yuge Ji‡

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China
Bing Han‡

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China
Hongbin Liu

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China
Di Song∗

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China
Lei Liu ∗

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China

^bSchool of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China

^cShenzhen Research Institute of Shandong University, Shenzhen 518057, P. R. of China
Gang Wang∗

^aSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, P. R. of China

Abstract

Alle Artikel dieser Rubrik

Abstract

We herein report an iron(salan)-catalyzed cross-dehydrogenative coupling of thiols with P(O)H compounds for the efficient synthesis of a range of thiophosphates, thiophosphinates, and thiophosphinites. This mild and practical method employs environmentally benign air as terminal oxidant, and earth-abundant metal iron at a low loading as catalyst, and exhibits broad substrate scope and good functional group tolerance, which is applicable to bioactive molecule preparation.

Key words

iron catalysis - P(O)–S bond formation - cross-dehydrogenative coupling - thiophosphates - synthetic methods

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Referenzen

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