Download PDF
Synthesis
DOI: 10.1055/a-2600-4572
paper

Iron-Catalyzed P(O)−S Bond Formation through Cross-dehydrogenative Coupling of Thiols with P(O)H Compounds

Yuge Ji
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
,
Bing Han
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
,
Hongbin Liu
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
,
Di Song
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
,
Lei Liu 
2   Chemistry and Chemical Engineering, Shandong University, Jinan, China (Ringgold ID: RIN12589)
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
3   Shenzhen Research Institute, Shandong University, Jinan, China (Ringgold ID: RIN12589)
,
Gang Wang
1   School of Pharmaceutical Sciences, Shandong First Medical University, Jinan, China (Ringgold ID: RIN518873)
› Author AffiliationsSupported by: Taishan Scholar Program at Shandong Province
Supported by: Natural Science Foundation of Shandong ZR2022QB007,ZR2023QH409,ZR2024MB056
Supported by: Natural Science Foundation of China 22301164,22425108,82404420
Supported by: Shenzhen Special Funds JCYJ20220530141205011
› Further Information
  PDF Download All articles of this category

We herein report an iron(salan)-catalyzed cross-dehydrogenative coupling of thiols with P(O)H compounds for the efficient synthesis of a range of thiophosphates, thiophosphinates, and thiophosphinites. This mild and practical method employs environmentally benign air as terminal oxidant, and earth-abundant metal iron at a low loading as catalyst, and exhibits broad substrate scope and good functional-group tolerance, which is applicable to bioactive molecules preparation.



Publication History

Received: 27 March 2025

Accepted after revision: 05 May 2025

Accepted Manuscript online:
05 May 2025

© . Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany