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Synthesis 2025; 57(16): 2462-2471
DOI: 10.1055/a-2608-1058
DOI: 10.1055/a-2608-1058
paper
Lipase-Catalyzed Esterification of Protected Amides under Ultrasound Irradiation via N–C(O) Cleavage
Abstract
A novel ultrasound-assisted protocol has been devised for the highly chemoselective esterification of tert-butyloxycarbonyl (Boc)-activated secondary carboxamides with alcohols. This study highlights the catalytic versatility of PPL lipase, which extends beyond their traditional hydrolytic functions to include synthetic applications like esterification and transesterification. The research investigates the enzymatic esterification of protected amides with alcohols, utilizing PPL lipase as a biocatalyst under ultrasound irradiation. This method can achieve high reaction rates and selectivities under mild conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2608-1058.
- Supporting Information
Publication History
Received: 04 April 2025
Accepted after revision: 14 May 2025
Accepted Manuscript online:
14 May 2025
Article published online:
04 June 2025
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