Abstract
The incorporation of fluorine into organic molecules holds significant value. The
three-component reaction provides a more convenient approach for the synthesis of
organofluorine compounds. Radical monofluorination will be fully discussed in this
review. Besides, other methods like transition metal-catalyzed, electrophilic, nucleophilic,
and carbine-mediated conditions will also be discussed. There are two main methods
for producing monofluorinated compounds: forming C–F bonds using fluorinating agents
or creating C–C bonds with fluorinated substrates. The latter method boasts a wider
range of applicable substrates. We will discuss reactions involving various substrates,
including NFSI, KHF2, Selectfluor, FABI, Et3N·3HF, COF2, ICH2F, DAST, and others. We will review the advancements made over the past decade (2014–2024)
and offer explanations of the underlying mechanisms. Additionally, how the additive
reagents work will also be discussed.
Keywords
Monofluorination - Radical - Three-component
