Synthesis, Inhaltsverzeichnis Synthesis 2025; 57(18): 2709-2715DOI: 10.1055/a-2631-4457 Paper I2-DMSO-Mediated Three-Component Cyclization of 2-Aminobenzimidazole to Access 2,3-Substituted Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives Authors Institutsangaben Mengyi Guo 1 Department of Pharmacy, Maternal and Child Health Hospital of Rongchang, Chongqing, China (Ringgold ID: RIN592401) Qian Guo 2 Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, China (Ringgold ID: RIN12550) Wei Yuan 1 Department of Pharmacy, Maternal and Child Health Hospital of Rongchang, Chongqing, China (Ringgold ID: RIN592401) Shenkun Liao 1 Department of Pharmacy, Maternal and Child Health Hospital of Rongchang, Chongqing, China (Ringgold ID: RIN592401) Luoteng Cheng 2 Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, China (Ringgold ID: RIN12550) JianYong Yuan 2 Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, China (Ringgold ID: RIN12550) Artikel empfehlen Abstract Artikel einzeln kaufen(opens in new window) Alle Artikel dieser Rubrik(opens in new window) Abstract An I2-DMSO-mediated, one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine-2,3-diylbis(phenylmethyl ketone) derivatives have been developed using 2-aminobenzimidazole, acetophenone, and enaminone as starting materials. The structures of the compounds were characterized by single-crystal X-ray diffraction. Keywords KeywordsBenzo[4,5]imidazo[1,2-a]pyrimidine-2,3-diylbis(phenylmethyl ketone) - Enaminone - I2-DMSO-mediated - Three-component reaction - Metal-free Volltext Referenzen References 1 Fedotov VV, Rusinov VL, Ulomsky EN, Mukhin EM, Gorbunov EB, Chupakhin ON. Chem Heterocycl Compd 2021; 57 (04) 383-409 2a Qin Z, Ma R, Ying S, Li F, Ma Y. Adv Synth Catal 2022; 364 (18) 3263-3272 2b Qin Z, Zhang R, Ying S, Ma Y. Org Chem Front 2022; 9 (20) 5624-5630 3 Zhang W, Arteaga J, Cashion DK. et al. J Alzheimer’s Dis 2012; 31: 601-612 4a Andrzejewska M, Yépez-Mulia L, Cedillo-Rivera R. et al. Eur J Med Chem 2002; 37 (12) 973-978 4b LaBarbera DV, Skibo EB. Bioorg Med Chem 2005; 13 (02) 387-395 4c Tardy S, Orsato A, Mologni L. et al. Bioorg Med Chem 2014; 22 (04) 1303-1312 5 Sondhi SM, Rani R, Singh J, Roy P, Agrawal SK, Saxena AK. Bioorg Med Chem Lett 2010; 20 (07) 2306-2310 6a Ansari KF, Lal C. Eur J Med Chem 2009; 44 (10) 4028-4033 6b Achar KCS, Hosamani KM, Seetharamareddy HR. Eur J Med Chem 2010; 45 (05) 2048-2054 6c Debnath S, Parveen S, Pradhan P, Das I, Das T. New J Chem 2022; 46 (22) 10504-10534 6d Algul O, Meric A, Polat S, Didem Yuksek N, Serin MS. Cent Eur J Chem 2009; 7 (03) 337-342 6e Osyanin VА, Osipov DV, Korzhenko KS, Demidov OP, Klimochkin YN. Chem Heterocycl Compd 2021; 57 (05) 588-593 7 Tseng S-S, Epstein JW, Brabander HJ, Francisco G. J Heterocycl Chem 1987; 24 (03) 837-843 8 Rao C, Mai S, Song Q. Org Lett 2017; 19 (18) 4726-4729 9 Guo M, Huang X, Li S. et al. J Org Chem 2023 10a Zhuang S-Y, Tang Y-X, Liu J-Y. et al. Org Lett 2022; 24 (15) 2858-2862 10b Huang C, Zhou Y, Yu X-X, Wang L-S, Wu Y-D, Wu A-X. J Org Chem 2021; 86 (23) 16916-16925 11a Lei S-G, Zhou Y, Wang L-S. et al. Org Chem Front 2023; 10 (19) 4843-4847 11b Vadagaonkar KS, Kalmode HP, Murugan K, Chaskar A. RSC Adv 2015; 5 (08) 5580-5590 Zusatzmaterial Zusatzmaterial Ergänzendes Material (PDF)
