Green Light-Driven Reduction of Methylenemalononitriles with Formate as a Reductant Without a Thiol Hydrogen-Atom-Transfer Catalyst

Yong-Qing Yang; Jialu Liu; Zheng Lu; Ximing Xu

doi:10.1055/a-2641-8389

Synthesis, Inhaltsverzeichnis

Synthesis 2025; 57(19): 2861-2868
DOI: 10.1055/a-2641-8389

Paper

Green Light-Driven Reduction of Methylenemalononitriles with Formate as a Reductant Without a Thiol Hydrogen-Atom-Transfer Catalyst

Authors

Yong-Qing Yang

¹School of Pharmacy, Jiangsu University, Zhenjiang, P.R. China
Jialu Liu

¹School of Pharmacy, Jiangsu University, Zhenjiang, P.R. China
Zheng Lu

¹School of Pharmacy, Jiangsu University, Zhenjiang, P.R. China
Ximing Xu

¹School of Pharmacy, Jiangsu University, Zhenjiang, P.R. China

Abstract

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Abstract

The reduction of methylenemalononitriles to their corresponding methylmalononitriles represents an important transformation in organic synthesis, owing to the ready availability of these starting materials. Herein, we report a safe, cost-effective, and practical photochemical reduction employing readily accessible organophotocatalyst and formate without thiol-mediated HAT catalysts. This method accommodates a broad substrate scope, including diverse (hetero)aryl-substituted methylenemalononitriles, delivering moderate to excellent yields.

Keywords

Photoreduction - Methylenemalononitrile - Formate - Green light - Rose Bengal - No thiol

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Referenzen

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