physioscience, Table of Contents physioscience 2025; 21(04): 149-151DOI: 10.1055/a-2668-0824 Editorial Core GRADE für Evidenzsynthesen Article in several languages: deutsch | English Authors Tobias Braun Recommend Article Abstract Buy Article(opens in new window) Full Text References References 1 Atkins D, Best D, Briss PA. et al. Grading quality of evidence and strength of recommendations. BMJ 2004; 328: 1490 2 Guyatt G, Hultcrantz M, Agoritsas T. et al. Why Core GRADE is needed: introduction to a new series in The BMJ. BMJ 2025; 389: e081902 3 Brignardello-Petersen R, Guyatt GH. Assessing the certainty of the evidence in systematic reviews: importance, process, and use. Am J Epidemiol 2025; 194: 1681-1686 4 Guyatt GH, Oxman AD, Kunz R. et al. What is “quality of evidence” and why is it important to clinicians?. BMJ 2008; 336: 995-998 5 Guyatt GH, Oxman AD, Vist GE. et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336: 924-926 6 Schünemann HJ. GRADE: Von der Evidenz zur Empfehlung. Beschreibung des Systems und Lösungsbeitrag zur Übertragbarkeit von Studienergebnissen. Z Evid Fortbild Qual Gesundhwes 2009; 103: 391-400 7 Guyatt GH, Oxman AD, Schünemann HJ. et al. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol 2011; 64: 380-382 8 Brennan SE, Johnston RV. Research Note: Interpreting findings of a systematic review using GRADE methods. J Physiother 2023; 69: 198-202 9 Neumann I, Schünemann H. , Hrsg. The GRADE Book version 1.0 (updated September 2024). The GRADE Working Group;. 2024 10 The GRADE Working Group Organizations, Hrsg. Welcome to the GRADE working group. Accessed September 11, 2025 at: https://www.gradeworkinggroup.org 11 Schünemann HJ, Schünemann AHJ, Oxman AD. et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ 2008; 336: 1106-1110 12 Iorio A, Spencer FA, Falavigna M. et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ 2015; 350: h870 13 Page MJ, Shamseer L, Altman DG. et al. Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study. PLoS Med 2016; 13: e1002028 14 Meneses AC de, Lopes GCM, Lima LB de. et al. Transparency of Systematic Reviews on Interventions for Multiple Sclerosis: Adherence to the GRADE Approach – Meta-Research. Neuroepidemiology 2025; 1-6 15 Hilton Boon M, Thomson H, Shaw B. et al. Challenges in applying the GRADE approach in public health guidelines and systematic reviews: a concept article from the GRADE Public Health Group. J Clin Epidemiol 2021; 135: 42-53 16 Izcovich A, Chu DK, Mustafa RA. et al. A guide and pragmatic considerations for applying GRADE to network meta-analysis. BMJ 2023; 381: e074495 17 Andrić A, Poklepović Peričić T, Tokalić R. et al. Experiences and challenges faced by systematic review authors in using the GRADE approach: a qualitative study. J Clin Epidemiol 2025; 185: 111870 18 Guyatt G, Agoritsas T, Brignardello-Petersen R. et al. Core GRADE 1: overview of the Core GRADE approach. BMJ 2025; 389: e081903 19 Guyatt G, Zeng L, Brignardello-Petersen R. et al. Core GRADE 2: choosing the target of certainty rating and assessing imprecision. BMJ 2025; 389: e081904 20 Guyatt G, Schandelmaier S, Brignardello-Petersen R. et al. Core GRADE 3: rating certainty of evidence-assessing inconsistency. BMJ 2025; 389: e081905 21 Guyatt G, Wang Y, Eachempati P. et al. Core GRADE 4: rating certainty of evidence-risk of bias, publication bias, and reasons for rating up certainty. BMJ 2025; 389: e083864 22 Guyatt G, Iorio A, Beer H de. et al. Core GRADE 5: rating certainty of evidence-assessing indirectness. BMJ 2025; 389: e083865 23 Guyatt G, Yao L, Murad MH. et al. Core GRADE 6: presenting the evidence in summary of findings tables. BMJ 2025; 389: e083866 24 Guyatt G, Vandvik PO, Iorio A. et al. Core GRADE 7: principles for moving from evidence to recommendations and decisions. BMJ 2025; 389: e083867