Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms

Yingying Zhou; Jianguo Zhang; Qingqing Xia; Lingmin Zhang; Miaomiao Zhang; Lijun Lu; Zaixing Yang; Jie Li

doi:10.1055/a-2696-1032

Planta Medica, Table of Contents

Planta Med
DOI: 10.1055/a-2696-1032

Reviews

Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms

Authors

Yingying Zhou‡

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Jianguo Zhang‡

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Qingqing Xia

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Lingmin Zhang

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Miaomiao Zhang

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Lijun Lu

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Zaixing Yang

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China
Jie Li

Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First Peopleʼs Hospital, Taizhou, Zhejiang Province, China

Abstract

Ovatodiolide, a macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica, exhibits diverse pharmacological activities in recent research. Its antitumor effects involve modulation of key signaling pathways (e.g., NF-κB/MMP-9, JAK2/STAT3, PI3K/AKT/mTOR, and Wnt/β-catenin) and effective targeting of cancer stem cells. For anti-fibrotic activity, it suppresses the TGF-β pathway and directly inhibits glucose-6-phosphate dehydrogenase. Additionally, it demonstrates antiviral, antibacterial, and anti-inflammatory activities. This review comprehensively summarizes current knowledge on ovatodiolide, including its discovery, synthesis, pharmacological actions, and underlying molecular mechanisms against target diseases. A deeper understanding of ovatodiolideʼs multifaceted pharmacological activities and mechanisms of action will accelerate its clinical translation as a therapeutic agent.

Keywords

ovatodiolide - Anisomeles indica - Labiatae - antimicrobial - antitumor - anti-inflammation - anti-fibrosis

Full Text

References

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