Abstract
Purpose
Acne vulgaris, a prevalent inflammatory skin condition, impacts both
appearance and quality of life, especially in adolescents. This study
explores a novel treatment combining black seed oil, rosehip oil, and
retinol within a nanoemulsion to improve therapeutic efficacy, drug
delivery, and patient compliance while minimizing side effects.
Methods
A nanoemulsion incorporating black seed oil, rosehip oil, and retinol was
developed and characterized. Antimicrobial activity was evaluated via in
vitro assays, while anti-inflammatory potential was assessed using standard
models. HaCaT cell lines were used to determine cell viability. The
formulation’s performance was compared with commercially available Retino AC
gel, focusing on stability, penetration, and overall effectiveness.
Results
The nanoemulsion showed strong antimicrobial effects against acne-related
microbes, reduced inflammatory markers, and preserved high cell viability,
confirming its biocompatibility. The combined action of black seed oil’s
anti-inflammatory and antioxidant properties, rosehip oil’s sebum-regulating
effects, and retinol’s ability to promote cell turnover enhanced overall
therapeutic outcomes. Compared to Retino AC gel, the nanoemulsion
demonstrated superior efficacy, stability, and potential for better patient
adherence.
Conclusion
This study presents a synergistic, nature-based, and nano-enabled approach to
treating acne and scars. The nanoemulsion offers a promising alternative to
conventional therapies by improving effectiveness and safety. These results
support further clinical development and highlight the potential of
combining natural ingredients with advanced delivery systems for managing
acne vulgaris.
Keywords
acne vulgaris - nanoemulsion gel - retinol - black seed oil - rose hip oil
Schlüsselwörter
anti-microbial
