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DOI: 10.1055/a-2718-7219
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Contemporary Insights into Triazole Derivative Synthesis and Biological Functions

Authors

  • Khushboo Singh

    1   Chemistry, University of Lucknow, Lucknow, India (Ringgold ID: RIN30096)

  • Arpit Srivastav

    1   Chemistry, University of Lucknow, Lucknow, India (Ringgold ID: RIN30096)

  • Ravi Kumar Shukla

    1   Chemistry, University of Lucknow, Lucknow, India (Ringgold ID: RIN30096)

  • Abhishek Srivastava

    2   Department of Chemistry, GLA University, Mathura, India (Ringgold ID: RIN231522)

  • Vinay Kumar Singh 

    1   Chemistry, University of Lucknow, Lucknow, India (Ringgold ID: RIN30096)

Gefördert durch: Department of Higher Education, Government of UP Project ID-39/2024/242/sattar-4-2024-001
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Abstract Triazoles, which are nitrogen-containing heterocyclic scaffolds, are being extensively explored by medicinal chemists for their versatile pharmacological activities and serve as a requisite anchor for novel drug discovery in medicinal chemistry. Several synthetic methods for triazoles and their derivatives are reviewed, with an emphasis on advancements that optimize yield, efficiency, and structural diversity. Triazoles and their derivatives are synthesized via various synthetic strategies, including novel click synthesis, microwave-assisted synthesis, organo-catalyst, metal catalyst, metal-free, and green synthesis approaches, showing immense pharmacological potential for instance antibacterial, inflammatory inhibition, antioxidant, antimicrobial, and anti-cancer activities. This study explores 10 years (2015-2025) of data published in high-impact journals regarding sustainable synthesis and various therapeutic activities of triazoles and their derivatives, alongside their structural diversity and sensing nature



Publikationsverlauf

Eingereicht: 31. Juli 2025

Angenommen nach Revision: 08. Oktober 2025

Accepted Manuscript online:
08. Oktober 2025

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