Streamlined Synthesis of Bulky (Dispersion Energy Donor) Iodobenzenes

Michael Fuhrmann; Nils F Hacket; Peter Richard Schreiner

doi:10.1055/a-2722-7141

Synthesis, Table of Contents

Synthesis
DOI: 10.1055/a-2722-7141

Paper

Streamlined Synthesis of Bulky (Dispersion Energy Donor) Iodobenzenes

Authors

Michael Fuhrmann

¹Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)
Nils F Hacket

¹Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)
Peter Richard Schreiner

¹Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany (Ringgold ID: RIN9175)

Abstract

PDF Download All articles of this category

We report an efficient synthesis of meta-substituted iodobenzenes from readily available starting materials. Negishi coupling utilizing Knochel’s protocol followed by iodination provides the desired compounds in excellent yields over two steps from readily available precursors. These iodobenzenes equipped with dispersion energy donors (DEDs) serve as building blocks for catalysts as demonstrated in the Corey-Bakshi-Shibata (CBS) reduction.

PDF (6339 kb)