An efficient, facile and one-pot four-component methodology for the cyclization of
readily available benzyl alcohols, acetophenones, Meldrum's acid and NH 4 OAc to access
dihydropyridinones (valuable scaffolds in medicinal and synthetic organic chemistry)
was established. This four-component cyclization reaction supports the straightforward
manufacture of several dihydropyridinones. Several C-C and C-N bonds were constructs
to synthesize the desired product. Readily available starting, operational simplicity,
mild reaction conditions, good to excellent reaction yields, and tolerate various
functional groups are the interesting features of this protocol.
