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DOI: 10.1055/a-2726-4234
Scalable and Selective Electrochemical Benzylic C–H Fluoroetherfication to Fluorinated Ethers
Authors
This work is supported by the School foundation of Wuhan Institute of Technology (NO. K2023008.).
Abstract
Electrochemical dehydrogenative cross-coupling reaction has become a powerful strategy to construct C–O bonds. However, electrochemically induced benzylic C–H fluoroetherfication still remains a challenge due to the limitations of prefunctionalization, using metal catalysts and chemical oxidants, multiple steps, and a narrow substrate scope. Herein, we present a green and efficient approach to synthesize diverse fluorinated ethers using ethylbenzenes and fluoroalcohols as substrates. This protocol exhibited good scalability. Mechanistic insights suggested that radicals might be involved in this reaction.
Publication History
Received: 17 September 2025
Accepted after revision: 17 October 2025
Accepted Manuscript online:
17 October 2025
Article published online:
13 November 2025
© 2025. Thieme. All rights reserved.
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