Abstract
Background
Gangliocytomas of the sellar region are rare, well-differentiated, benign tumors that
may coexist with pituitary adenomas, forming so-called “collision tumors.” These lesions
often present with endocrine dysfunction, most commonly acromegaly.
Case Description
We report a 69-year-old female who presented with drug-resistant headaches, acromegalic
features, and signs of Cushing's disease. Magnetic resonance imaging showed a sellar
mass with extension into the clivus. Endoscopic transsphenoidal resection revealed
a tumor composed of ganglion cells and adenohypophyseal components. Immunohistochemistry
confirmed a diagnosis of gangliocytoma coexisting with a hormone-secreting pituitary
adenoma. Postoperative hormonal normalization was achieved.
Conclusion
Sellar gangliocytomas with dual hormonal activity pose diagnostic challenges and highlight
the importance of histological and immunohistochemical evaluation. Awareness of these
rare entities can prevent misdiagnosis and support appropriate surgical management.
Keywords
acromegaly - collision tumor - cushing disease - gangliocytoma - pituitary adenoma
