The Association of In Vitro Fertilization and Perinatal Morbidity

Suleena Kansal Kalra; Thomas A. Molinaro

doi:10.1055/s-0028-1087108

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2008; 26(5): 423-435
DOI: 10.1055/s-0028-1087108

The Association of In Vitro Fertilization and Perinatal Morbidity

Suleena Kansal Kalra¹ , Thomas A. Molinaro¹

¹Division of Reproductive Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

ABSTRACT

In recent years, there has been increasing concern regarding the safety of in vitro fertilization (IVF) because of the potential health impact on these infants. Multiple pregnancy contributes the vast majority of morbidity associated with IVF and, initially, many thought that adverse outcomes after IVF were solely attributable to the high incidence of twin pregnancies. More recently, multiple studies have suggested that IVF singleton pregnancies may be at increased risk for preterm birth, low birth weight, congenital anomalies, perinatal mortality, and several other pregnancy-related complications compared with unassisted singleton pregnancies. We have focused this review on the increased risk of adverse outcomes in IVF singleton conceptions compared with that of unassisted conceptions. The available evidence evaluating the association between IVF and low birth weight, preterm delivery, placental abruption, preeclampsia, congenital anomalies, and perinatal mortality in singleton pregnancies is summarized. In addition, data reporting an increased risk of congenital and chromosomal anomalies after IVF are presented.

KEYWORDS

In vitro fertilization (IVF) - adverse outcome - congenital anomalies - IUGR - antepartum risk - preterm delivery

Volltext

Referenzen

REFERENCES

1 Centers for Disease Control .Assisted reproductive technology report. Available at: http://www.cdc.gov/ART/ Accessed July 17, 2008
2 Helmerhorst F M, Perquin D A, Donker D, Keirse M J. Perinatal outcome of singletons and twins after assisted conception; a systematic review of controlled studies. BMJ. 2004; 328 261-265
3 Pinborg A. IVF/ICSI twin pregnancies: risk and prevention. Hum Reprod Update. 2005; 11 575-593
4 Van Voorhis B J. Outcomes from assisted reproductive technology. Obstet Gynecol. 2006; 107 183-200
5 Schieve L A, Meikle S F, Ferre C, Peterson H B, Jeng G, Wilcox L S. Low and very low birth weight in infants conceived with the use of assisted reproductive technology. N Engl J Med. 2002; 346 731-737
6 Dhont M, DeSutter P, Ruyssinck G, Martens G, Bekaert A. Perinatal outcome of pregnancies after assisted reproduction: a case control study. Am J Obstet Gynecol. 1999; 181 688-695
7 Jackson R, Gibson K A, Wu Y W, Croughan M S. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol. 2004; 103 551-563
8 Schieve L A, Ferre C, Peterson H B, Macaluso M, Reynolds M A, Wright V C. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol. 2004; 103 1144-1153
9 Shevell T, Malone F D, Vidaver J et al.. Assisted reproductive technology and pregnancy outcome. Obstet Gynecol. 2005; 106 1039-1045
10 Wright V C, Chang J, Jeng G, Chen M, Macaluso M. Assisted reproductive technology surveillance - United States, 2004. MMWR Surveill Summ. 2007; 56 1-22
11 Reynolds M A, Schieve L A, Martin J A, Jeng G, Macaluso M. Trends in multiple births conceived using assisted reproductive technology, United States, 1997–2000. Pediatrics. 2003; 111 1159-1162
12 Centers for Disease Control .Assisted reproductive technology report. http://www.cdc.gov/ART/ART2004/ Accessed July 17, 2008
13 Pinborg A, Loft A, Nyboe Anderson A. Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: the role of twin pregnancy. Acta Obstet Gynecol Scand. 2004; 83 1071-1078
14 Draper E S, Kurinczuk J J, Abrams K R, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis. Lancet. 1999; 353 1746-1749
15 Olivennes F, Rufat P, Andre B, Pourade A, Quiros M C, Frydman R. The increased risk of complication observed in singleton pregnancies resulting from in-vitro fertilization (IVF) does not seem to be related to the IVF method itself. Hum Reprod. 1993; 8 1297-1300
16 Källén B, Olausson P O, Nygren K G. Neonatal outcome in pregnancies from ovarian stimulation. Obstet Gynecol. 2002; 100 414-419
17 Kapiteijn K, de Bruijn C S, de Boer E et al.. Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation?. Hum Reprod. 2006; 21 3228-3234
18 Wang Y A, Sullivan E A, Black D, Dean J, Bryant J, Chapman M. Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000. Fertil Steril. 2005; 83 1650-1658
19 Chung K, Coutifaris C, Chalian R et al.. Factors influencing adverse perinatal outcomes in pregnancies achieved through us of assisted reproductive technology. Fertil Steril. 2006; 86 1634-1641
20 Buckett W M, Chian R C, Holzer H, Dean N, Usher R, Tan S L. Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstet Gynecol. 2007; 110 885-891
21 Bowen J R, Gibson F L, Garth I L, Saunders D M. Medical and Developmental outcome at 1 year in infants conceived by intracytoplasmic sperm injection. Lancet. 1998; 351 1529-1534
22 Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk J J. Assisted reproductive technologies and the risk of birth defects—a systematic review. Hum Reprod. 2005; 20 328-338
23 Klemetti R, Gissler M, Sevon T, Koivurova S, Ritvanen A, Hemminki E. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil Steril. 2005; 84 1300-1307
24 Erikson A, Kalien B. Congenital Malformations in infants born after IVF: a population based study. Hum Reprod. 2001; 16 504-509
25 Sutcliffe A G, Saunders K, McLachlan R et al.. A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil Steril. 2003; 79 512-516
26 Place I, Englert Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil Steril. 2003; 80 1388-1398
27 Bonduelle M, Liebaers I, Deketelaere V et al.. Neonatal data on a cohort of 2889 infants born after ICSI (1991–1999) and of 2995 infants born after IVF (1983–1999). Hum Reprod. 2002; 17 671-694
28 Bonduelle M, Wennerholm U B, Loft A et al.. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod. 2005; 20 413-419
29 Bergh T, Ericson A, Hillensjo T, Nygren K G, Wennerholm U B. Deliveries and children born after in-vitro fertilisation in Sweden 1982–95: a retrospective cohort study. Lancet. 1999; 354 1579-1585
30 Källén B, Finnström O, Nygren K G, Olausson P O. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res A Clin Mol Teratol. 2005; 73 162-169
31 Olson C K, Keppler-Noreuil K, Romitti P et al.. In vitro fertilization is increased with an increase in major birth defects. Fertil Steril. 2005; 84 1308-1315
32 Silver R I, Rodriguez R, Chang T S, Gearhart J P. In vitro fertilization is associated with an increased risk of hypospadias. J Urol. 1999; 161 1954-1957
33 Zhu J L, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006; 333 679-683
34 Merlob P, Sapir O, Sulkes J, Fisch B. The prevalence of major congenital malformations during two periods of time, 1986–1994 and 1995–2002 in newborns conceived by assisted reproduction technology. Eur J Med Genet. 2005; 48 5-11
35 Hansen M, Kurinczuk J J, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002; 346 725-730
36 Agarwal P, Loh S, Lim S et al.. Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study. BJOG. 2005; 112 1376-1383
37 Belva F, Henriet S, Liebaers I, Van Steirteghem A, Celestin-Westreich S, Bonduelle M. Medical outcome of 8-year-old singleton ICSI children (born > or = 32 weeks' gestation) and a spontaneously conceived comparison group. Hum Reprod. 2007; 22 506-515
38 Van Steirteghem A, Bonduelle M, Devroey P, Liebaers I. Follow-up of children born after ICSI. Hum Reprod Update. 2002; 8 111-116
39 Fedder J, Gabrielsen A, Humaidan P, Erb K, Ernst E, Loft A. Malformation rate and sex ratio in 412 children conceived with epididymal or testicular sperm. Hum Reprod. 2007; 22 1080-1085
40 Katalinic A, Rösch C, Ludwig M. German ICSI Follow-Up Study Group . Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril. 2004; 81 1604-1616
41 Rimm A A, Katayama A C, Diaz M, Katayama K P. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet. 2004; 21 437-443
42 Reddy U M, Wapner R J, Rebar R W, Tasca R J. Infertility, assisted reproductive technology, and adverse pregnancy outcomes:executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2007; 109 967-977
43 Schreurs A, Legius E, Meuleman C, Fryns J P, D'Hooghe T M. Increased frequency of chromosomal abnormalities in female partners of couples undergoing in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril. 2000; 74 94-96
44 Foresta C, Garolla A, Bartoloni L, Bettella A, Ferlin A. Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. J Clin Endocrinol Metab. 2005; 90 152-156
45 Riccaboni A, Lalatta F, Caliari I, Bonetti S, Somigliana E, Ragni G. Genetic screening in 2,710 infertile candidate couples for assisted reproductive techniques: results of application of Italian guidelines for the appropriate use of genetic tests. Fertil Steril. 2008; 89 800-808
46 Shevell T, Malone F D, Vidaver J et al.. Assisted reproductive technology and pregnancy outcome. Obstet Gynecol. 2005; 106(5 Pt 1) 1039-1045
47 Tarlatzis B C, Grimbizis G. Pregnancy and child outcome after assisted reproduction techniques. Hum Reprod. 1999; 14(Suppl) 231-242
48 Bonduelle M, Wilikens A, Buysse A et al.. Prospective follow-up study of 877 children born after intracytoplasmic sperm injection (ICSI), with ejaculated epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI. Hum Reprod. 1996; 11(Suppl 4) 131-155
49 Bonduelle M, Van Assche E, Joris H et al.. Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Hum Reprod. 2002; 17 2600-2614
50 Gosden R, Trasler J, Lucifero D, Faddy M. Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet. 2003; 361 1975-1977
51 Cox G F, Burger J, Lip V et al.. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet. 2002; 71 162-164
52 Ludwig M, Katalinic A, Gross S, Sutcliffe A, Varon R, Horsthemke B. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet. 2005; 42 289-291
53 Debaun M R, Niemitz E L, Feinberg A P. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19 . Am J Hum Genet. 2003; 72 156-160
54 Gicquel C, Gaston V, Mandelbaum J, Siffroi J P, Flahault A, Le Bouc Y. In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet. 2003; 72 1338-1341
55 Sutcliffe A G, Peters C J, Bowdin S et al.. Assisted reproductive therapies and imprinting disorders—a preliminary British survey. Hum Reprod. 2006; 21 1009-1011
56 Allen C, Reardon W. Assisted reproduction technology and defects of genomic imprinting. BJOG. 2005; 112 1589-1594
57 Orstavik K H, Eiklid K, Van Der Hagen C B et al.. Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic sperm injection. Am J Hum Genet. 2003; 72 218-219
58 Thompson J R, Williams C J. Genomic imprinting and assisted reproductive technology: connections and potential risks. Semin Reprod Med. 2005; 23 285-295
59 Arnaud P, Feil R. Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction. Birth Defects Res C Embryo Today. 2005; 75 81-97
60 Bowdin S, Brueton L, Allen C et al.. A survey of assisted reproductive technology births and imprinting disorders. Hum Reprod. 2007; 22 3237-3240
61 Lidegaard O, Pinborg A, Andersen A N. Imprinting diseases and IVF: Danish National IVF cohort study. Hum Reprod. 2005; 20 950-954
62 Doornbos M E, Maas S M, McDonnell J, Vermeiden J P, Hennekam R C. Infertility, assisted reproduction technologies and imprinting disturbances: a Dutch study. Hum Reprod. 2007; 22 2476-2480
63 Khosla S, Dean W, Brown D, Reik W, Feil R. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod. 2001; 64 918-926
64 Doyle P, Bunch K J, Beral V, Draper G J. Cancer incidence in children conceived with assisted reproduction technology. Lancet. 1998; 352 452-453
65 Klip H, Burger C W, de Kraker J, van Leeuwen F E. OMEGA-project group. Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Hum Reprod. 2001; 16 2451-2458
66 Bruinsma F, Venn A, Lancaster P, Speirs A, Healy D. Incidence of cancer in children born after in-vitro fertilization. Hum Reprod. 2000; 15 604-607
67 Moll A C, Imhof S M, Cruysberg J RM, Schouten-van Meeteren A YN, Boers M, van Leeuwen F E. Incidence of retinoblastoma in children born after in vitro fertilisation. Lancet. 2003; 361 309-310
68 Bradbury B D, Jick H. In vitro fertilization and childhood retinoblastoma. Br J Clin Pharmacol. 2004; 58 209-211
69 Leslie G I, Gibson F L, McMahon C, Cohen J, Saunders D M, Tennant C. Children conceived using ICSI do not have increased risk of delayed mental development at 5 years of age. Hum Reprod. 2003; 18 2067-2072
70 Bonduelle M, Ponjaert I, Van Steirteghem A, Derde A P, Devroey P, Liebaers I. Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF. Hum Reprod. 2003; 18 342-350
71 Koivurova S, Hartikainen A L, Gissler M, Hemminki E, Sovio U, Jarvelin M R. Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod. 2002; 17 1391-1398
72 Koivurova S, Hartikainen A L, Sovio U, Gissler M, Hemminki E, Jarvelin M R. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod. 2003; 18 2328-2336
73 Leunens L, Celestin-Westreich S, Bonduelle M, Liebaers I, Ponjaert-Kristoffersen I. Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children. Hum Reprod. 2008; 23 105-111
74 Knoester M, Helmerhorst F M, van der Westerlaken L A, Walther F J, Veen S. Matched follow-up study of 5–8 year old ICSI singletons: child behavior, parenting stress and child (health-related) quality of life. Hum Reprod. 2007; 22 3098-3107
75 Knoester M, Vandenbroucke J P, Helmerhorst F M, van der Westerlaken L A, Walther F J, Veen S. Matched follow-up study of 5–8 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons. Hum Reprod. 2007; 22 1638-1646
76 Wennerholm U B, Bonduelle M, Sutcliffe A et al.. Paternal sperm concentration and growth and cognitive development in children born with a gestational age more than 32 weeks after assisted reproductive therapy. Hum Reprod. 2006; 21 1514-1520
77 Ponjaert-Kristoffersen I, Bonduelle M, Barnes J et al.. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics. 2005; 115 e283-e289
78 Stromberg B, Dahquist G, Ericson A, Finnstrom O, Koster M, Stjernqvist K. Neurological sequelae in children born after in-vitro fertilization: a population based study. Lancet. 2002; 359 461-465
79 Kallen B, Finnstrim O, Nyguen K G, Olavsson P O. In vitro fertilization (IVF) in Sweden: Risk for congenital malformation after different IVF methods. Birth Defects Res A Clin MoL Teratol. 2005; 73 162-169

Suleena Kansal KalraM.D.

Division of Reproductive Endocrinology, University of Pennsylvania

3701 Market Street, Suite 800, Philadelphia, PA 19104

eMail: skalra@obgyn.upenn.edu