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Synfacts 2009(2): 0128-0128  
DOI: 10.1055/s-0028-1087607
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Platencin

Contributor(s): Philip Kocienski, Stewart Eccles
S. Y. Yun, J.-C. Zheng, D. Lee*
University of Illinois at Chicago, USA
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Publikationsverlauf

Publikationsdatum:
22. Januar 2009 (online)

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Significance

Platencin was isolated from a new strain of Streptomyces platensis. It has sparked a great deal of interest due to its novel mode of action and impressive antibiotic properties, especially against drug resistant bacterial strains. This synthesis relies upon a radical cyclization (E → F) to construct the key bicyclic ring system.