Synfacts 2009(2): 0228-0228  
DOI: 10.1055/s-0028-1087622
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Oxygenation of Primary Amines to Amides by Ru(OH)x/Al2O3

Contributor(s): Yasuhiro Uozumi, Yutaka Matsuura
J. W. Kim, K. Yamaguchi, N. Mizuno*
The University of Tokyo, Japan
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22. Januar 2009 (online)


The oxygenation of primary amines 2 took place in the presence of Ru(OH)x/Al2O3 catalyst 1 (5 mol% of Ru) in water under air to give the corresponding primary amides 3 in up to 92% yield (11 examples). After the reaction, the catalyst 1 was readily removed from the reaction mixture by simple filtration and reused without significant loss of its catalytic activity (83% yield of isolated benzamide 3a).