Synfacts 2009(2): 0223-0223  
DOI: 10.1055/s-0028-1087625
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Sequential Heck Coupling and Hydrogenation

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
M. L. Kantam*, R. Chakravarti, V. R. Chintareddy, B. Sreedhar, S. Bhargava
Indian Institute of Chemical Technology, Hyderabad, India and RMIT University, Melbourne, Australia
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22. Januar 2009 (online)


The nanocrystalline magnesium ­oxide stabilized palladium (NAPMgPd(0)) promoted the Heck coupling of haloarenes 1 with styrenes 2 and subsequent hydrogenation to give the corresponding dibenzyls 3 (19 examples, 75-98% yield). The catalyst also promoted the sequential reaction of 1 with acrylates 4 to afford the alkyl phenylpropionates 5 (8 examples, 78-90% yield).