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Direct Arylation of α-Substituted Pyridines and Quinolines
A. M. Berman, J. C. Lewis, R. G. Bergman*, J. A. Ellman*
University of California, Berkeley and Lawrence Berkeley National Laboratory, USA
22 January 2009 (online)
A Rh(I)-catalyzed C-H activation with subsequent arylation is reported in this article. The presence of a substituent in the 2-position of the pyridine ring is required for the reaction to proceed. This may be attributed to steric interactions that reduce the energy difference between the C-H activation intermediate and the N-bound complex.