Synfacts 2009(2): 0195-0195  
DOI: 10.1055/s-0028-1087659
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Arylation of α-Substituted Pyridines and Quinolines

Contributor(s): Paul Knochel, Tobias Thaler
A. M. Berman, J. C. Lewis, R. G. Bergman*, J. A. Ellman*
University of California, Berkeley and Lawrence Berkeley National Laboratory, USA
Further Information

Publication History

Publication Date:
22 January 2009 (online)


A Rh(I)-catalyzed C-H activation with subsequent arylation is reported in this article. The presence of a substituent in the 2-position of the pyridine ring is required for the reaction to proceed. This may be attributed to steric interactions that reduce the energy difference between the C-H activation intermediate and the N-bound complex.