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Synfacts 2009(4): 0439-0439  
DOI: 10.1055/s-0028-1087823
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Efficient Au(I)-Catalyzed Alkyne Hydration

Contributor(s): Paul Knochel, Andrei Gavryushin
N. Marion, R. S. Ramón, S. P. Nolan*
Institute of Chemical Research of Catalonia, Tarragona, Spain
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Alkyne hydration is a process of significant synthetic utility, considering the importance of carbonyl compound for modern organic synthesis. The authors reported here an extremely efficient and highly versatile protocol for Au-catalyzed alkyne hydration. Loading as low as 0.001 mol% is sufficient for some cases, which makes this process very attractive even for industrial application despite the high price of gold.