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Efficient Cobalt-Catalyzed Coupling of Aryl Grignard Reagents with Alkyl Bromides
G. Cahiez*, C. Chaboche, C. Duplais, A. Moyeux
CNRS - Université de Paris 13, Bobigny, France
23 March 2009 (online)
An efficient cobalt-catalyzed cross-coupling reaction of aryl Grignard reagents with primary and secondary alkyl bromides is reported. The reaction proceeds rapidly under very mild conditions and tolerates many functional groups. A readily available cobalt catalyst is used in the process, which is in general more efficient and versatile than the similar iron-catalyzed sp²-sp³ cross-coupling reactions.