Synfacts 2009(4): 0430-0430  
DOI: 10.1055/s-0028-1087828
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Intramolecular Hydroalkoxylation of Alkynyl Alcohols by Lanthanide Catalysts

Contributor(s): Paul Knochel, Tobias Thaler
S. Seo, X. Yu, T. J. Marks*
Northwestern University, Evanston, USA
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23. März 2009 (online)


A detailed study on the scope and mechanism of intramolecular hydroalkoxylation/cyclization via Ln[N(TMS)2]3 is presented. Thus, it is shown for instance, that the turnover frequencies (N f ) depend on the ionic radius of the Ln³+ employed (N f (La) > N f (Nd) > N f (Sm) > N f (Y) > N f (Lu).